DegronMD

Uniprot ID: Q9Y2M0

Source protein: Fanconi-associated nuclease 1

Source gene: FAN1

Class: DEG_SCF_FBW7_1

Location: 97:102

E3 ligase: FBXW7

DEGRON score: 0.8107

ASA_SCORE: 109.45

COIL: 0.9662

CONS_SCORE: 0.2407

DSS_SCORE: 0.6153

HELIX: 0.014

FCONS_SCORE: 1.0257

RIG_SCORE: 0.6599

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V92I	TCGA-A6-6653	COAD	TCGA	VTPKKS	DEG_SCF_FBW7_1	0.1944
p.V92I	DO10373	COAD	ICGC	VTPKKS	DEG_SCF_FBW7_1	0.1944
p.P99S	TCGA-AX-A1CE	UCEC	TCGA	VTPKKS	DEG_SCF_FBW7_1	0.6752
p.P99S	DO42280	UCEC	ICGC	VTPKKS	DEG_SCF_FBW7_1	0.6752
p.V97I	TCGA-D1-A0ZP	UCEC	TCGA	VTPKKS	DEG_SCF_FBW7_1	0.5965
p.V97I	DO42233	UCEC	ICGC	VTPKKS	DEG_SCF_FBW7_1	0.5965
p.T93A	SIDM00660	Colorectal Carcinoma	GDSC	VTPKKS	DEG_SCF_FBW7_1	0.2222
p.T93A	ACH-000985	Colon/Colorectal Cancer	CCLE	VTPKKS	DEG_SCF_FBW7_1	0.2222
p.T93A	LS-411N	large_intestine	COSMIC	VTPKKS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2M0	Fanconi-associated nuclease 1	DEG_SCF_FBW7_1	97:102	VTPKKS	FBXW7	0.8107	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons