DegronMD

Uniprot ID: Q9Y2M0

Source protein: Fanconi-associated nuclease 1

Source gene: FAN1

Class: DEG_SCF_FBW7_1

Location: 109:114

E3 ligase: FBXW7

DEGRON score: 0.9271

ASA_SCORE: 80.0667

COIL: 0.8975

CONS_SCORE: 0.2508

DSS_SCORE: 0.7315

HELIX: 0.076

FCONS_SCORE: 1.0347

RIG_SCORE: 0.6307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E120G	TCGA-17-Z030	LUAD	TCGA	LTPGQS	DEG_SCF_FBW7_1	0.1667
p.P111T	TCGA-EE-A2MM	SKCM	TCGA	LTPGQS	DEG_SCF_FBW7_1	0.7031
p.P111T	DO37770	SKCM	ICGC	LTPGQS	DEG_SCF_FBW7_1	0.7031
p.L109S	SIDM00210	Ovarian Carcinoma	GDSC	LTPGQS	DEG_SCF_FBW7_1	0.7667
p.L109S	SIDM00068	Colorectal Carcinoma	GDSC	LTPGQS	DEG_SCF_FBW7_1	0.7667
p.L109S	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPGQS	DEG_SCF_FBW7_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2M0	Fanconi-associated nuclease 1	DEG_SCF_FBW7_1	109:114	LTPGQS	FBXW7	0.9271	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons