DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
LTPGQS
Uniprot ID:
Q9Y2M0
Source protein:
Fanconi-associated nuclease 1
Source gene:
FAN1
Class:
DEG_SCF_FBW7_1
Location:
109:114
E3 ligase:
FBXW7
DEGRON score:
0.9271
ASA_SCORE:
80.0667
COIL:
0.8975
CONS_SCORE:
0.2508
DSS_SCORE:
0.7315
HELIX:
0.076
FCONS_SCORE:
1.0347
RIG_SCORE:
0.6307
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.L109S
SIDM00210
Ovarian Carcinoma
GDSC
LTPGQS
DEG_SCF_FBW7_1
0.7667
p.L109S
SIDM00068
Colorectal Carcinoma
GDSC
LTPGQS
DEG_SCF_FBW7_1
0.7667
p.L109S
SIDM01072
Squamous Cell Lung Carcinoma
GDSC
LTPGQS
DEG_SCF_FBW7_1
0.7667
p.P111T
TCGA-EE-A2MM
SKCM
TCGA
LTPGQS
DEG_SCF_FBW7_1
0.7031
p.P111T
DO37770
SKCM
ICGC
LTPGQS
DEG_SCF_FBW7_1
0.7031
p.E120G
TCGA-17-Z030
LUAD
TCGA
LTPGQS
DEG_SCF_FBW7_1
0.1667
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Drug responses associated with FAN1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of LTPGQS
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9Y2M0
Fanconi-associated nuclease 1
DEG_SCF_FBW7_1
109:114
LTPGQS
FBXW7
0.9271
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