DegronMD

Uniprot ID: Q15583

Source protein: Homeobox protein TGIF1

Source gene: TGIF1

Class: DEG_SCF_FBW7_1

Location: 265:272

E3 ligase: FBXW7

DEGRON score: 0.7917

ASA_SCORE: 89.8875

COIL: 0.7884

CONS_SCORE: 0.4479

DSS_SCORE: 0.4682

HELIX: 0.1845

FCONS_SCORE: 1.0356

RIG_SCORE: 0.7264

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S272Y	TCGA-D1-A103	UCEC	TCGA	LEETPFHS	DEG_SCF_FBW7_1	0.712
p.P279Q	TCGA-EE-A2ML	SKCM	TCGA	LEETPFHS	DEG_SCF_FBW7_1	0.1389
p.N278H	TCGA-PG-A917	UCEC	TCGA	LEETPFHS	DEG_SCF_FBW7_1	0.1667
p.A257T	DO224739	COCA	ICGC	LEETPFHS	DEG_SCF_FBW7_1	0.1111
p.E263D	DO229031	LICA	ICGC	LEETPFHS	DEG_SCF_FBW7_1	0.2778
p.A261P	DO42280	UCEC	ICGC	LEETPFHS	DEG_SCF_FBW7_1	0.2222
p.M256I	SIDM02041	Colorectal Carcinoma	GDSC	LEETPFHS	DEG_SCF_FBW7_1	0.0833
p.E263K	DJM-1	skin	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	0.2778
p.R260W	NCI-SNU-1	stomach	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	0.1944
p.E277K	DJM-1	skin	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	0.1944
p.R274W	NCI-SNU-1	stomach	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15583	Homeobox protein TGIF1	DEG_SCF_FBW7_1	265:272	LEETPFHS	FBXW7	0.7917	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons