DegronMD - Q15583(TGIF1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T70P	TCGA-77-8007	LUSC	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0833
p.T70P	DO26557	LUSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0833
p.S66P	TCGA-98-8023	LUSC	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1944
p.S66P	DO26668	LUSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1944
p.P64L	TCGA-BR-8382	STAD	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25
p.P64L	DO47925	STAD	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25
p.S272Y	TCGA-D1-A103	UCEC	TCGA	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation altering degron motif	0.712
p.D371N	TCGA-DU-6392	LGG	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation rewiring degron network	0.25
p.P279Q	TCGA-EE-A2ML	SKCM	TCGA	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.1389
p.L361F	TCGA-FI-A2D5	UCEC	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation altering degron motif	0.6981
p.P71L	TCGA-L5-A8NN	ESCA	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.N278H	TCGA-PG-A917	UCEC	TCGA	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.1667
p.P61T	TCGA-T2-A6WX	HNSC	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.5919
p.P61T	DO219065	HNSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.5919
p.P365S	TCGA-XF-AAMG	BLCA	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation altering degron motif	0.6752
p.W53C	DO7783	COAD	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.7
p.L50I	DO7783	COAD	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25
p.L50I	DO36881	READ	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25
p.L50I	ACH-000986	Colon/Colorectal Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25
p.L50I	HT-115	large intestine	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25
p.A257T	DO224739	COCA	ICGC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.1111
p.P43L	DO52474	COCA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.R58G	DO44454	HNSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.7568
p.K44N	DO21283	LAML	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0833
p.G55C	DO231943	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6489
p.L70F	DO228976	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0833
p.G55V	DO228985	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6421
p.E263D	DO229031	LICA	ICGC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.2778
p.R58L	DO229038	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.8428
p.V47L	DO29740	OV	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1667
p.P71R	DO49442	PACA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.S49P	DO227681	SKCA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.2222
p.A261P	DO42280	UCEC	ICGC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.2222
p.M256I	SIDM02041	Colorectal Carcinoma	GDSC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.0833
p.S53F	SIDM00969	Ovarian Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6871
p.S53F	SIDM00654	Small Cell Lung Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6871
p.S53F	SIDM00814	Other Solid Cancers	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6871
p.S53F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6871
p.S53F	SIDM01525	Acute Myeloid Leukemia	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.6871
p.T357I	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation rewiring degron network	0.2222
p.T357I	SIDM00701	Non-Cancerous	GDSC	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation rewiring degron network	0.2222
p.T357I	ACH-000311	Lung Cancer	CCLE	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation rewiring degron network	0.2222
p.A45D	SIDM00618	Hepatocellular Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1111
p.A45D	ACH-000620	Liver Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1111
p.A45D	JHH-1	liver	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1111
p.P71S	SIDM01781	Gastric Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.K68I	ACH-000617	Ovarian Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1389
p.K68I	OVCAR-4	ovary	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1389
p.H57Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation altering degron motif	0.7582
p.F362L	ACH-000999	Colon/Colorectal Cancer	CCLE	LFNTPPPT	DEG_SCF_FBW7_1	361:368	Mutation altering degron motif	0.587
p.R71S	SNU-C1	large intestine	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.0556
p.K48I	OVCAR-4	ovary	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.1944
p.E263K	DJM-1	skin	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.2778
p.R260W	NCI-SNU-1	stomach	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.1944
p.E277K	DJM-1	skin	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.1944
p.R274W	NCI-SNU-1	stomach	COSMIC	LEETPFHS	DEG_SCF_FBW7_1	265:272	Mutation rewiring degron network	0.2778
p.L64I	HT-115	large intestine	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	53:61	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGIF1

UniProt ID: Q15583

Entrez ID: 7050

Protein name: Homeobox protein TGIF1 (5'-TG-3'-interacting factor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGIF1 in