DegronMD

Uniprot ID: Q15583

Source protein: Homeobox protein TGIF1

Source gene: TGIF1

Class: DEG_APCC_DBOX_1

Location: 53:61

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9325

ASA_SCORE: 68.4667

COIL: 0.893

CONS_SCORE: 0.249

DSS_SCORE: 0.2924

HELIX: 0.0508

FCONS_SCORE: 1.3297

RIG_SCORE: 0.7386

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T70P	TCGA-77-8007	LUSC	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	0.0833
p.T70P	DO26557	LUSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0833
p.S66P	TCGA-98-8023	LUSC	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	0.1944
p.S66P	DO26668	LUSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.1944
p.P64L	TCGA-BR-8382	STAD	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.P64L	DO47925	STAD	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.P71L	TCGA-L5-A8NN	ESCA	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	0.0556
p.P61T	TCGA-T2-A6WX	HNSC	TCGA	SRGTLAYLP	DEG_APCC_DBOX_1	0.5919
p.P61T	DO219065	HNSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.5919
p.W53C	DO7783	COAD	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.7
p.L50I	DO7783	COAD	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.L50I	DO36881	READ	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.L50I	ACH-000986	Colon/Colorectal Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.L50I	HT-115	large_intestine	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.P43L	DO52474	COCA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0556
p.R58G	DO44454	HNSC	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.7568
p.K44N	DO21283	LAML	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0833
p.G55C	DO231943	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6489
p.L70F	DO228976	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0833
p.G55V	DO228985	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6421
p.R58L	DO229038	LICA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.8428
p.V47L	DO29740	OV	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.1667
p.P71R	DO49442	PACA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0556
p.S49P	DO227681	SKCA	ICGC	SRGTLAYLP	DEG_APCC_DBOX_1	0.2222
p.S53F	SIDM00969	Ovarian Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6871
p.S53F	SIDM00654	Small Cell Lung Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6871
p.S53F	SIDM00814	Other Solid Cancers	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6871
p.S53F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6871
p.S53F	SIDM01525	Acute Myeloid Leukemia	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.6871
p.A45D	SIDM00618	Hepatocellular Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.1111
p.A45D	ACH-000620	Liver Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	0.1111
p.A45D	JHH-1	liver	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	0.1111
p.P71S	SIDM01781	Gastric Carcinoma	GDSC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0556
p.K68I	ACH-000617	Ovarian Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	0.1389
p.K68I	OVCAR-4	ovary	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	0.1389
p.H57Q	ACH-000996	Endometrial/Uterine Cancer	CCLE	SRGTLAYLP	DEG_APCC_DBOX_1	0.7582
p.R71S	SNU-C1	large_intestine	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	0.0556
p.K48I	OVCAR-4	ovary	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	0.1944
p.L64I	HT-115	large_intestine	COSMIC	SRGTLAYLP	DEG_APCC_DBOX_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRGTLAYLP

Degron related mutations and impact score

Drug responses associated with TGIF1 mutations

All proteins holding degron of SRGTLAYLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15583	Homeobox protein TGIF1	DEG_APCC_DBOX_1	53:61	SRGTLAYLP	APC,CDC20,FZR1	0.9325	More...