DegronMD

Uniprot ID: Q15583

Source protein: Homeobox protein TGIF1

Source gene: TGIF1

Class: DEG_SCF_FBW7_1

Location: 361:368

E3 ligase: FBXW7

DEGRON score: 0.9903

ASA_SCORE: 84.8

COIL: 0.9566

CONS_SCORE: 0.5473

DSS_SCORE: 0.7199

HELIX: 0.0091

FCONS_SCORE: 1.1388

RIG_SCORE: 0.6362

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D371N	TCGA-DU-6392	LGG	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.25
p.L361F	TCGA-FI-A2D5	UCEC	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.6981
p.P365S	TCGA-XF-AAMG	BLCA	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.6752
p.T357I	SIDM00702	Non-Small Cell Lung Carcinoma	GDSC	LFNTPPPT	DEG_SCF_FBW7_1	0.2222
p.T357I	SIDM00701	Non-Cancerous	GDSC	LFNTPPPT	DEG_SCF_FBW7_1	0.2222
p.T357I	ACH-000311	Lung Cancer	CCLE	LFNTPPPT	DEG_SCF_FBW7_1	0.2222
p.F362L	ACH-000999	Colon/Colorectal Cancer	CCLE	LFNTPPPT	DEG_SCF_FBW7_1	0.587

DegronMD: protein-targeted degradation, mutation and drug response to degrons