DegronMD - Q9GZN2(TGIF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P175L	TCGA-21-1079	LUSC	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2222
p.P175L	DO26846	LUSC	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2222
p.P156S	TCGA-24-2030	OV	TCGA	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.6752
p.P156S	DO30590	OV	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.6752
p.P156L	TCGA-A2-A0EV	BRCA	TCGA	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.6471
p.P156L	DO4942	BRCA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.6471
p.A170D	TCGA-A5-A0G1	UCEC	TCGA	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1389
p.A170D	TCGA-A5-A0G1	UCEC	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0833
p.A170D	DO42472	UCEC	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1389
p.A170D	DO42472	UCEC	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0833
p.P188S	TCGA-EE-A29B	SKCM	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2778
p.P188S	DO47255	SKCM	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2778
p.E171K	TCGA-GU-AATO	BLCA	TCGA	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1111
p.E171K	TCGA-GU-AATO	BLCA	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1111
p.E171K	DO51893	BLCA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1111
p.E171K	DO51893	BLCA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1111
p.L157M	TCGA-MH-A560	KIRP	TCGA	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.5999
p.L157M	DO48474	KIRP	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.5999
p.G149R	DO233737	GACA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1389
p.E171D	DO228190	LICA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1111
p.E171D	DO228190	LICA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.1111
p.R169S	DO229031	LICA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1667
p.R169S	DO229031	LICA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0556
p.P175S	DO220877	MELA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.2222
p.F195L	SIDM00832	Colorectal Carcinoma	GDSC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0833
p.F195L	ACH-000680	Colon/Colorectal Cancer	CCLE	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0833
p.F195L	SW948	large intestine	COSMIC	LFNTPPPT	DEG_SCF_FBW7_1	179:186	Mutation rewiring degron network	0.0833
p.P160T	SIDM00878	Breast Carcinoma	GDSC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.7031
p.P160T	HCC1569	breast	COSMIC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation altering degron motif	0.7031
p.P147S	SIDM00217	Colorectal Carcinoma	GDSC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.0833
p.P147S	ACH-000999	Colon/Colorectal Cancer	CCLE	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.0833
p.P147S	SNU-1040	large intestine	COSMIC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.0833
p.R148H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1111
p.R148H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.1111
p.L164V	ACH-000872	Lung Cancer	CCLE	PLVTPGST	DEG_SCF_FBW7_1	156:163	Mutation rewiring degron network	0.3056

Kaplan plot for TGIF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TGIF2

UniProt ID: Q9GZN2

Entrez ID: 60436

Protein name: Homeobox protein TGIF2 (5'-TG-3'-interacting factor 2) (TGF-beta-induced transcription factor 2) (TGFB-induced factor 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TGIF2 in