DegronMD

Uniprot ID: Q9GZN2

Source protein: Homeobox protein TGIF2

Source gene: TGIF2

Class: DEG_SCF_FBW7_1

Location: 156:163

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 69.6375

COIL: 0.9153

CONS_SCORE: 0.4552

DSS_SCORE: 0.6316

HELIX: 0.0381

FCONS_SCORE: 1.1625

RIG_SCORE: 0.6789

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P156S	TCGA-24-2030	OV	TCGA	PLVTPGST	DEG_SCF_FBW7_1	0.6752
p.P156S	DO30590	OV	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.6752
p.P156L	TCGA-A2-A0EV	BRCA	TCGA	PLVTPGST	DEG_SCF_FBW7_1	0.6471
p.P156L	DO4942	BRCA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.6471
p.A170D	TCGA-A5-A0G1	UCEC	TCGA	PLVTPGST	DEG_SCF_FBW7_1	0.1389
p.A170D	DO42472	UCEC	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.1389
p.E171K	TCGA-GU-AATO	BLCA	TCGA	PLVTPGST	DEG_SCF_FBW7_1	0.1111
p.E171K	DO51893	BLCA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.1111
p.L157M	TCGA-MH-A560	KIRP	TCGA	PLVTPGST	DEG_SCF_FBW7_1	0.5999
p.L157M	DO48474	KIRP	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.5999
p.G149R	DO233737	GACA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.1389
p.E171D	DO228190	LICA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.1111
p.R169S	DO229031	LICA	ICGC	PLVTPGST	DEG_SCF_FBW7_1	0.1667
p.P160T	SIDM00878	Breast Carcinoma	GDSC	PLVTPGST	DEG_SCF_FBW7_1	0.7031
p.P160T	HCC1569	breast	COSMIC	PLVTPGST	DEG_SCF_FBW7_1	0.7031
p.P147S	SIDM00217	Colorectal Carcinoma	GDSC	PLVTPGST	DEG_SCF_FBW7_1	0.0833
p.P147S	ACH-000999	Colon/Colorectal Cancer	CCLE	PLVTPGST	DEG_SCF_FBW7_1	0.0833
p.P147S	SNU-1040	large_intestine	COSMIC	PLVTPGST	DEG_SCF_FBW7_1	0.0833
p.R148H	SIDM00412	B-Cell Non-Hodgkin's Lymphoma	GDSC	PLVTPGST	DEG_SCF_FBW7_1	0.1111
p.R148H	WSU-NHL	haematopoietic_and_lymphoid_tissue	COSMIC	PLVTPGST	DEG_SCF_FBW7_1	0.1111
p.L164V	ACH-000872	Lung Cancer	CCLE	PLVTPGST	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9GZN2	Homeobox protein TGIF2	DEG_SCF_FBW7_1	156:163	PLVTPGST	FBXW7	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons