DegronMD

Uniprot ID: Q9GZN2

Source protein: Homeobox protein TGIF2

Source gene: TGIF2

Class: DEG_SCF_FBW7_1

Location: 179:186

E3 ligase: FBXW7

DEGRON score: 0.9982

ASA_SCORE: 81.125

COIL: 0.9396

CONS_SCORE: 0.4799

DSS_SCORE: 0.8518

HELIX: 0.0088

FCONS_SCORE: 1.1496

RIG_SCORE: 0.6085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P175L	TCGA-21-1079	LUSC	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.2222
p.P175L	DO26846	LUSC	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.2222
p.A170D	TCGA-A5-A0G1	UCEC	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.0833
p.A170D	DO42472	UCEC	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.0833
p.P188S	TCGA-EE-A29B	SKCM	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.2778
p.P188S	DO47255	SKCM	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.2778
p.E171K	TCGA-GU-AATO	BLCA	TCGA	LFNTPPPT	DEG_SCF_FBW7_1	0.1111
p.E171K	DO51893	BLCA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.1111
p.E171D	DO228190	LICA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.1111
p.R169S	DO229031	LICA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.0556
p.P175S	DO220877	MELA	ICGC	LFNTPPPT	DEG_SCF_FBW7_1	0.2222
p.F195L	SIDM00832	Colorectal Carcinoma	GDSC	LFNTPPPT	DEG_SCF_FBW7_1	0.0833
p.F195L	ACH-000680	Colon/Colorectal Cancer	CCLE	LFNTPPPT	DEG_SCF_FBW7_1	0.0833
p.F195L	SW948	large_intestine	COSMIC	LFNTPPPT	DEG_SCF_FBW7_1	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons