DegronMD

Uniprot ID: P46821

Source protein: Microtubule-associated protein 1B

Source gene: MAP1B

Class: DEG_SCF_FBW7_2

Location: 1267:1274

E3 ligase: FBXW7

DEGRON score: 0.9857

ASA_SCORE: 100.6125

COIL: 0.907

CONS_SCORE: 0.6136

DSS_SCORE: 0.6227

HELIX: 0.0395

FCONS_SCORE: 1.0877

RIG_SCORE: 0.6268

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1262Y	TCGA-AA-3697	COAD	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.6389
p.S1262Y	DO8424	COAD	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.6389
p.P1261S	TCGA-AJ-A3EK	UCEC	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.1667
p.P1261S	TCGA-EE-A20C	SKCM	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.1667
p.P1261S	DO222775	MELA	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.1667
p.P1261S	DO47665	SKCM	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.1667
p.P1261S	DO41584	UCEC	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.1667
p.K1269N	TCGA-AZ-4315	COAD	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.5806
p.K1269N	DO8842	COAD	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.5806
p.L1272M	TCGA-BA-6869	HNSC	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.5999
p.L1272M	DO14250	HNSC	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.5999
p.R1275H	TCGA-BR-4371	STAD	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275H	TCGA-C5-A1MI	CESC	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275H	TCGA-CH-5738	PRAD	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275H	DO6249	CESC	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275H	DO36370	PRAD	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275H	DO38348	STAD	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.G1273D	TCGA-EO-A22R	UCEC	TCGA	LEKTPLGE	DEG_SCF_FBW7_2	0.6087
p.G1273D	DO42713	UCEC	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.6087
p.P1271R	DO228106	EOPC	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.7512
p.R1275C	DO233888	GACA	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275C	SIDM00782	Colorectal Carcinoma	GDSC	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275C	ACH-000381	Colon/Colorectal Cancer	CCLE	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.R1275C	T84	large_intestine	COSMIC	LEKTPLGE	DEG_SCF_FBW7_2	0.3056
p.P1261L	DO220902	MELA	ICGC	LEKTPLGE	DEG_SCF_FBW7_2	0.1667
p.S1258P	SIDM00453	Pancreatic Carcinoma	GDSC	LEKTPLGE	DEG_SCF_FBW7_2	0.5278
p.S1258P	ACH-000023	Pancreatic Cancer	CCLE	LEKTPLGE	DEG_SCF_FBW7_2	0.5278
p.S1258P	PA-TU-8988T	pancreas	COSMIC	LEKTPLGE	DEG_SCF_FBW7_2	0.5278

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEKTPLGE

Degron related mutations and impact score

Drug responses associated with MAP1B mutations

All proteins holding degron of LEKTPLGE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46821	Microtubule-associated protein 1B	DEG_SCF_FBW7_2	1267:1274	LEKTPLGE	FBXW7	0.9857	More...