DegronMD

Uniprot ID: O75553

Source protein: Disabled homolog 1

Source gene: DAB1

Class: LIG_APCC_ABBA_1

Location: 279:284

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7477

ASA_SCORE: 82.4333

COIL: 0.5812

CONS_SCORE: 0.6005

DSS_SCORE: 0.5454

HELIX: 0.369

FCONS_SCORE: 1.3064

RIG_SCORE: 0.7715

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L279V	TCGA-05-4420	LUAD	TCGA	LELFGD	LIG_APCC_ABBA_1	0.5654
p.P273Q	TCGA-38-4629	LUAD	TCGA	LELFGD	LIG_APCC_ABBA_1	0.1667
p.V289I	TCGA-AJ-A3EK	UCEC	TCGA	LELFGD	LIG_APCC_ABBA_1	0.1944
p.A283T	TCGA-AU-6004	COAD	TCGA	LELFGD	LIG_APCC_ABBA_1	0.7139
p.Q277K	TCGA-DS-A1OC	CESC	TCGA	LELFGD	LIG_APCC_ABBA_1	0.2778
p.S287R	TCGA-EB-A430	SKCM	TCGA	LELFGD	LIG_APCC_ABBA_1	0.25
p.F291V	TCGA-EE-A3J5	SKCM	TCGA	LELFGD	LIG_APCC_ABBA_1	0.1389
p.A279T	DO230343	COCA	ICGC	LELFGD	LIG_APCC_ABBA_1	0.7139
p.V271L	DO234410	ESAD	ICGC	LELFGD	LIG_APCC_ABBA_1	0.1111
p.Q274K	DO26414	LUAD	ICGC	LELFGD	LIG_APCC_ABBA_1	0.3056
p.Q274K	DO32049	OV	ICGC	LELFGD	LIG_APCC_ABBA_1	0.3056
p.P269A	DO45332	LUAD	ICGC	LELFGD	LIG_APCC_ABBA_1	0.0556
p.P282T	DO24860	LUAD	ICGC	LELFGD	LIG_APCC_ABBA_1	0.7031
p.P269S	DO26938	LUSC	ICGC	LELFGD	LIG_APCC_ABBA_1	0.0556
p.P269S	DO37778	SKCM	ICGC	LELFGD	LIG_APCC_ABBA_1	0.0556
p.P276L	DO37419	SKCM	ICGC	LELFGD	LIG_APCC_ABBA_1	0.25
p.T283I	DO42033	UCEC	ICGC	LELFGD	LIG_APCC_ABBA_1	0.7078
p.V286A	DO42977	UCEC	ICGC	LELFGD	LIG_APCC_ABBA_1	0.2778
p.L289S	DO42913	UCEC	ICGC	LELFGD	LIG_APCC_ABBA_1	0.1944
p.A294D	ACH-000012	Lung Cancer	CCLE	LELFGD	LIG_APCC_ABBA_1	0.0556
p.A294D	ACH-000029	Lung Cancer	CCLE	LELFGD	LIG_APCC_ABBA_1	0.0556
p.A294D	ACH-000993	Endometrial/Uterine Cancer	CCLE	LELFGD	LIG_APCC_ABBA_1	0.0556
p.P289L	GP5d	large_intestine	COSMIC	LELFGD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75553	Disabled homolog 1	LIG_APCC_ABBA_1	279:284	LELFGD	APC,CDC20,FZR1	0.7477	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons