DegronMD

Uniprot ID: Q96RD9

Source protein: Fc receptor-like protein 5

Source gene: FCRL5

Class: LIG_APCC_ABBA_1

Location: 676:681

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6276

ASA_SCORE: 41.45

COIL: 0.0128

CONS_SCORE: 0.3915

DSS_SCORE: 0.0637

HELIX: 0.0008

FCONS_SCORE: 1.2952

RIG_SCORE: 0.9257

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q669H	TCGA-39-5021	LUSC	TCGA	LELHCE	LIG_APCC_ABBA_1	0.1389
p.Q669H	DO27397	LUSC	ICGC	LELHCE	LIG_APCC_ABBA_1	0.1389
p.L683M	TCGA-85-7697	LUSC	TCGA	LELHCE	LIG_APCC_ABBA_1	0.2778
p.L683M	DO27053	LUSC	ICGC	LELHCE	LIG_APCC_ABBA_1	0.2778
p.A670D	TCGA-DU-6392	LGG	TCGA	LELHCE	LIG_APCC_ABBA_1	0.1667
p.A670D	DO22237	LGG	ICGC	LELHCE	LIG_APCC_ABBA_1	0.1667
p.L690M	TCGA-E6-A1LX	UCEC	TCGA	LELHCE	LIG_APCC_ABBA_1	0.0833
p.L690M	DO41020	UCEC	ICGC	LELHCE	LIG_APCC_ABBA_1	0.0833
p.S687F	TCGA-EB-A431	SKCM	TCGA	LELHCE	LIG_APCC_ABBA_1	0.1667
p.S687F	DO37671	SKCM	ICGC	LELHCE	LIG_APCC_ABBA_1	0.1667
p.R667W	TCGA-FU-A40J	CESC	TCGA	LELHCE	LIG_APCC_ABBA_1	0.0833
p.R667W	DO44314	CESC	ICGC	LELHCE	LIG_APCC_ABBA_1	0.0833
p.R667W	ACH-000872	Lung Cancer	CCLE	LELHCE	LIG_APCC_ABBA_1	0.0833
p.P688Q	TCGA-IN-AB1X	STAD	TCGA	LELHCE	LIG_APCC_ABBA_1	0.1389
p.P688Q	DO222334	STAD	ICGC	LELHCE	LIG_APCC_ABBA_1	0.1389
p.A682V	DO234275	ESAD	ICGC	LELHCE	LIG_APCC_ABBA_1	0.3056
p.V671L	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LELHCE	LIG_APCC_ABBA_1	0.1944
p.V671L	H513	pleura	COSMIC	LELHCE	LIG_APCC_ABBA_1	0.1944
p.I689V	SIDM01133	Other Solid Cancers	GDSC	LELHCE	LIG_APCC_ABBA_1	0.1111
p.I689V	SIDM00930	Osteosarcoma	GDSC	LELHCE	LIG_APCC_ABBA_1	0.1111
p.I689V	SIDM00531	Pancreatic Carcinoma	GDSC	LELHCE	LIG_APCC_ABBA_1	0.1111
p.I689V	SIDM01525	Acute Myeloid Leukemia	GDSC	LELHCE	LIG_APCC_ABBA_1	0.1111
p.S687C	SIDM00774	Breast Carcinoma	GDSC	LELHCE	LIG_APCC_ABBA_1	0.1667
p.S687C	ACH-000691	Breast Cancer	CCLE	LELHCE	LIG_APCC_ABBA_1	0.1667
p.S687C	HCC2157	breast	COSMIC	LELHCE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96RD9	Fc receptor-like protein 5	LIG_APCC_ABBA_1	676:681	LELHCE	APC,CDC20,FZR1	0.6276	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons