DegronMD

Uniprot ID: P14923

Source protein: Junction plakoglobin

Source gene: JUP

Class: LIG_APCC_ABBA_1

Location: 714:719

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9607

ASA_SCORE: 71.9333

COIL: 0.7255

CONS_SCORE: 0.2404

DSS_SCORE: 0.4384

HELIX: 0.2188

FCONS_SCORE: 0.7918

RIG_SCORE: 0.734

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P713Q	TCGA-46-3765	LUSC	TCGA	LEMHMD	LIG_APCC_ABBA_1	0.3056
p.P713Q	DO26959	LUSC	ICGC	LEMHMD	LIG_APCC_ABBA_1	0.3056
p.P725H	TCGA-HE-7129	KIRP	TCGA	LEMHMD	LIG_APCC_ABBA_1	0.1667
p.P725H	DO20786	KIRP	ICGC	LEMHMD	LIG_APCC_ABBA_1	0.1667
p.M720V	DO50906	LICA	ICGC	LEMHMD	LIG_APCC_ABBA_1	0.3056
p.M718T	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEMHMD	LIG_APCC_ABBA_1	0.6312
p.M718T	ACH-001638	Lymphoma	CCLE	LEMHMD	LIG_APCC_ABBA_1	0.6312
p.D719E	SIDM01617	Endometrial Carcinoma	GDSC	LEMHMD	LIG_APCC_ABBA_1	0.5647
p.D719E	ACH-000994	Endometrial/Uterine Cancer	CCLE	LEMHMD	LIG_APCC_ABBA_1	0.5647

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P14923	Junction plakoglobin	LIG_APCC_ABBA_1	714:719	LEMHMD	APC,CDC20,FZR1	0.9607	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons