DegronMD - P14923(JUP)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P713Q	TCGA-46-3765	LUSC	TCGA	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation rewiring degron network	0.3056
p.P713Q	DO26959	LUSC	ICGC	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation rewiring degron network	0.3056
p.S36F	TCGA-EE-A29M	SKCM	TCGA	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.S36F	DO37404	SKCM	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.S38N	TCGA-EE-A2GO	SKCM	TCGA	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.0556
p.S38N	DO37823	SKCM	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.0556
p.D23N	TCGA-F5-6814	READ	TCGA	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation altering degron motif	0.6932
p.D23N	DO36556	READ	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation altering degron motif	0.6932
p.E15K	TCGA-FD-A62P	BLCA	TCGA	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.E15K	DO44054	BLCA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111
p.G29S	TCGA-FS-A1Z0	SKCM	TCGA	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.3056
p.G29S	DO37431	SKCM	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.3056
p.P725H	TCGA-HE-7129	KIRP	TCGA	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation rewiring degron network	0.1667
p.P725H	DO20786	KIRP	ICGC	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation rewiring degron network	0.1667
p.S24L	DO225391	BRCA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation altering degron motif	0.8778
p.N31K	DO228926	LICA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.25
p.M720V	DO50906	LICA	ICGC	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation rewiring degron network	0.3056
p.A30T	DO228138	PBCA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.2778
p.T19I	SIDM00001	Other Blood Cancers	GDSC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation blocking phosphorylation signal	0.6667
p.V34M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1667
p.S28L	SIDM01147	Gastric Carcinoma	GDSC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation altering degron motif	0.7667
p.S28L	ACH-000427	Gastric Cancer	CCLE	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation altering degron motif	0.7667
p.S28L	NCI-N87	stomach	COSMIC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation altering degron motif	0.7667
p.M718T	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation altering degron motif	0.6312
p.M718T	ACH-001638	Lymphoma	CCLE	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation altering degron motif	0.6312
p.D719E	SIDM01617	Endometrial Carcinoma	GDSC	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation altering degron motif	0.5647
p.D719E	ACH-000994	Endometrial/Uterine Cancer	CCLE	LEMHMD	LIG_APCC_ABBA_1	714:719	Mutation altering degron motif	0.5647
p.V37I	ACH-000667	Lung Cancer	CCLE	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.0833
p.V37I	HCC-44	lung	COSMIC	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.0833
p.S36P	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGIHS	DEG_SCF_TRCP1_1	23:28	Mutation rewiring degron network	0.1111

Kaplan plot for JUP in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

JUP

UniProt ID: P14923

Entrez ID: 3728

Protein name: Junction plakoglobin (Catenin gamma) (Desmoplakin III) (Desmoplakin-3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for JUP in