DegronMD

Uniprot ID: P14923

Source protein: Junction plakoglobin

Source gene: JUP

Class: DEG_SCF_TRCP1_1

Location: 23:28

E3 ligase: BTRC

DEGRON score: 0.998

ASA_SCORE: 53.6833

COIL: 0.703

CONS_SCORE: 0.5197

DSS_SCORE: 0.3014

HELIX: 0.215

FCONS_SCORE: 1.2415

RIG_SCORE: 0.7306

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S36F	TCGA-EE-A29M	SKCM	TCGA	DSGIHS	DEG_SCF_TRCP1_1	0.1111
p.S36F	DO37404	SKCM	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.1111
p.S38N	TCGA-EE-A2GO	SKCM	TCGA	DSGIHS	DEG_SCF_TRCP1_1	0.0556
p.S38N	DO37823	SKCM	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.0556
p.D23N	TCGA-F5-6814	READ	TCGA	DSGIHS	DEG_SCF_TRCP1_1	0.6932
p.D23N	DO36556	READ	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.6932
p.E15K	TCGA-FD-A62P	BLCA	TCGA	DSGIHS	DEG_SCF_TRCP1_1	0.1111
p.E15K	DO44054	BLCA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.1111
p.G29S	TCGA-FS-A1Z0	SKCM	TCGA	DSGIHS	DEG_SCF_TRCP1_1	0.3056
p.G29S	DO37431	SKCM	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.3056
p.S24L	DO225391	BRCA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.8778
p.N31K	DO228926	LICA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.25
p.A30T	DO228138	PBCA	ICGC	DSGIHS	DEG_SCF_TRCP1_1	0.2778
p.T19I	SIDM00001	Other Blood Cancers	GDSC	DSGIHS	DEG_SCF_TRCP1_1	0.6667
p.V34M	SIDM01263	T-Lymphoblastic Leukemia	GDSC	DSGIHS	DEG_SCF_TRCP1_1	0.1667
p.S28L	SIDM01147	Gastric Carcinoma	GDSC	DSGIHS	DEG_SCF_TRCP1_1	0.7667
p.S28L	ACH-000427	Gastric Cancer	CCLE	DSGIHS	DEG_SCF_TRCP1_1	0.7667
p.S28L	NCI-N87	stomach	COSMIC	DSGIHS	DEG_SCF_TRCP1_1	0.7667
p.V37I	ACH-000667	Lung Cancer	CCLE	DSGIHS	DEG_SCF_TRCP1_1	0.0833
p.V37I	HCC-44	lung	COSMIC	DSGIHS	DEG_SCF_TRCP1_1	0.0833
p.S36P	ACH-000984	Endometrial/Uterine Cancer	CCLE	DSGIHS	DEG_SCF_TRCP1_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons