DegronMD

Uniprot ID: Q9Y2I1

Source protein: Nischarin

Source gene: NISCH

Class: DEG_SCF_FBW7_2

Location: 1279:1286

E3 ligase: FBXW7

DEGRON score: 0.9549

ASA_SCORE: 89.6875

COIL: 0.8603

CONS_SCORE: 0.4832

DSS_SCORE: 0.3496

HELIX: 0.1064

FCONS_SCORE: 1.0831

RIG_SCORE: 0.6841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1275M	TCGA-AP-A0LM	UCEC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	0.2222
p.V1275M	DO43306	UCEC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.2222
p.S1277A	TCGA-CC-A7IE	LIHC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	0.2778
p.S1277A	DO52175	LIHC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.2778
p.S1278Y	TCGA-DK-A2I1	BLCA	TCGA	LERTPSPE	DEG_SCF_FBW7_2	0.3056
p.S1278Y	DO444	BLCA	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.3056
p.K1290N	TCGA-EC-A1QX	UCEC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	0.6667
p.K1290N	DO42592	UCEC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.6667
p.F1296L	TCGA-EY-A1GI	UCEC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	0.0556
p.F1296L	DO41211	UCEC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.0556
p.P1283L	TCGA-QB-AA9O	SKCM	TCGA	LERTPSPE	DEG_SCF_FBW7_2	0.7582
p.P1283L	DO51267	SKCM	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.7582
p.S1294F	DO220906	MELA	ICGC	LERTPSPE	DEG_SCF_FBW7_2	0.5556
p.V1274A	SIDM01608	Endometrial Carcinoma	GDSC	LERTPSPE	DEG_SCF_FBW7_2	0.1944
p.V1274A	ACH-000990	Endometrial/Uterine Cancer	CCLE	LERTPSPE	DEG_SCF_FBW7_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I1	Nischarin	DEG_SCF_FBW7_2	1279:1286	LERTPSPE	FBXW7	0.9549	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons