DegronMD - Q9Y2I1(NISCH)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1275M	TCGA-AP-A0LM	UCEC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.2222
p.V1275M	DO43306	UCEC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.2222
p.S1277A	TCGA-CC-A7IE	LIHC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.2778
p.S1277A	DO52175	LIHC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.2778
p.S1278Y	TCGA-DK-A2I1	BLCA	TCGA	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.3056
p.S1278Y	DO444	BLCA	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.3056
p.K1290N	TCGA-EC-A1QX	UCEC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation blocking ubiquitination signal	0.6667
p.K1290N	DO42592	UCEC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation blocking ubiquitination signal	0.6667
p.F1296L	TCGA-EY-A1GI	UCEC	TCGA	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.0556
p.F1296L	DO41211	UCEC	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.0556
p.P1283L	TCGA-QB-AA9O	SKCM	TCGA	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation altering degron motif	0.7582
p.P1283L	DO51267	SKCM	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation altering degron motif	0.7582
p.R248C	DO233760	GACA	ICGC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.2222
p.E269G	DO10975	GBM	ICGC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.1389
p.E267D	DO228974	LICA	ICGC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.1944
p.S1294F	DO220906	MELA	ICGC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation blocking phosphorylation signal	0.5556
p.S253L	DO222702	MELA	ICGC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation altering degron motif	0.7667
p.V247A	DO229257	THCA	ICGC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.1944
p.S263T	SIDM01119	Other Solid Cancers	GDSC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.3056
p.V259A	SIDM00845	Burkitt's Lymphoma	GDSC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation altering degron motif	0.6936
p.R248L	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.2222
p.R248L	ACH-000861	Lung Cancer	CCLE	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.2222
p.R248L	HOP-62	lung	COSMIC	TSMKEVLVPEA	DEG_COP1_1	252:262	Mutation rewiring degron network	0.2222
p.V1274A	SIDM01608	Endometrial Carcinoma	GDSC	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.1944
p.V1274A	ACH-000990	Endometrial/Uterine Cancer	CCLE	LERTPSPE	DEG_SCF_FBW7_2	1279:1286	Mutation rewiring degron network	0.1944

Kaplan plot for NISCH in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NISCH

UniProt ID: Q9Y2I1

Entrez ID: 11188

Protein name: Nischarin (Imidazoline receptor 1) (I-1) (IR1) (Imidazoline receptor antisera-selected protein) (hIRAS) (Imidazoline-1 receptor) (I1R) (Imidazoline-1 receptor candidate protein) (I-1 receptor candidate protein) (I1R candidate protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NISCH in