DegronMD

Uniprot ID: Q9Y2I1

Source protein: Nischarin

Source gene: NISCH

Class: DEG_COP1_1

Location: 252:262

E3 ligase: COP1

DEGRON score: 0.936

ASA_SCORE: 51.0182

COIL: 0.4892

CONS_SCORE: 0.5485

DSS_SCORE: 0.3343

HELIX: 0.4271

FCONS_SCORE: 1.0461

RIG_SCORE: 0.7874

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R248C	DO233760	GACA	ICGC	TSMKEVLVPEA	DEG_COP1_1	0.2222
p.E269G	DO10975	GBM	ICGC	TSMKEVLVPEA	DEG_COP1_1	0.1389
p.E267D	DO228974	LICA	ICGC	TSMKEVLVPEA	DEG_COP1_1	0.1944
p.S253L	DO222702	MELA	ICGC	TSMKEVLVPEA	DEG_COP1_1	0.7667
p.V247A	DO229257	THCA	ICGC	TSMKEVLVPEA	DEG_COP1_1	0.1944
p.S263T	SIDM01119	Other Solid Cancers	GDSC	TSMKEVLVPEA	DEG_COP1_1	0.3056
p.V259A	SIDM00845	Burkitt's Lymphoma	GDSC	TSMKEVLVPEA	DEG_COP1_1	0.6936
p.R248L	SIDM00133	Non-Small Cell Lung Carcinoma	GDSC	TSMKEVLVPEA	DEG_COP1_1	0.2222
p.R248L	ACH-000861	Lung Cancer	CCLE	TSMKEVLVPEA	DEG_COP1_1	0.2222
p.R248L	HOP-62	lung	COSMIC	TSMKEVLVPEA	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2I1	Nischarin	DEG_COP1_1	252:262	TSMKEVLVPEA	COP1	0.936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons