DegronMD

Uniprot ID: Q9BR77

Source protein: Coiled-coil domain-containing protein 77

Source gene: CCDC77

Class: DEG_SCF_FBW7_1

Location: 37:44

E3 ligase: FBXW7

DEGRON score: 0.9994

ASA_SCORE: 80.1875

COIL: 0.909

CONS_SCORE: 0.6237

DSS_SCORE: 0.6408

HELIX: 0.0754

FCONS_SCORE: 1.1372

RIG_SCORE: 0.6341

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E46K	TCGA-3B-A9HT	SARC	TCGA	LESTPLPS	DEG_SCF_FBW7_1	0.2778
p.E46K	SIDM00971	Breast Carcinoma	GDSC	LESTPLPS	DEG_SCF_FBW7_1	0.2778
p.R48H	TCGA-CM-6162	COAD	TCGA	LESTPLPS	DEG_SCF_FBW7_1	0.2222
p.R48H	SIDM00518	Mesothelioma	GDSC	LESTPLPS	DEG_SCF_FBW7_1	0.2222
p.R48H	H290	pleura	COSMIC	LESTPLPS	DEG_SCF_FBW7_1	0.2222
p.S44F	TCGA-DA-A95W	SKCM	TCGA	LESTPLPS	DEG_SCF_FBW7_1	0.9093
p.E38V	DO222877	COCA	ICGC	LESTPLPS	DEG_SCF_FBW7_1	0.6582
p.E42K	DO218943	LUAD	ICGC	LESTPLPS	DEG_SCF_FBW7_1	0.7022
p.K29Q	DO46352	OV	ICGC	LESTPLPS	DEG_SCF_FBW7_1	0.5556
p.K32N	DO36556	READ	ICGC	LESTPLPS	DEG_SCF_FBW7_1	0.1944
p.E53D	DO50291	SKCM	ICGC	LESTPLPS	DEG_SCF_FBW7_1	0.0833
p.K33T	DO47743	STAD	ICGC	LESTPLPS	DEG_SCF_FBW7_1	0.2222
p.S44Y	SIDM01201	Other Blood Cancers	GDSC	LESTPLPS	DEG_SCF_FBW7_1	0.8231
p.S44Y	ACH-002289	Leukemia	CCLE	LESTPLPS	DEG_SCF_FBW7_1	0.8231
p.S44Y	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	LESTPLPS	DEG_SCF_FBW7_1	0.8231
p.R31K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LESTPLPS	DEG_SCF_FBW7_1	0.1667
p.R31K	ACH-000929	Lung Cancer	CCLE	LESTPLPS	DEG_SCF_FBW7_1	0.1667
p.R31K	NCI-H2110	lung	COSMIC	LESTPLPS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BR77	Coiled-coil domain-containing protein 77	DEG_SCF_FBW7_1	37:44	LESTPLPS	FBXW7	0.9994	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons