DegronMD - Q9BR77(CCDC77)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E46K	TCGA-3B-A9HT	SARC	TCGA	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.2778
p.E46K	SIDM00971	Breast Carcinoma	GDSC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.2778
p.V17F	TCGA-43-8118	LUSC	TCGA	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.0833
p.V17F	DO45471	LUSC	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.0833
p.N2S	TCGA-BG-A222	UCEC	TCGA	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.5958
p.N2S	DO42977	UCEC	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.5958
p.R14Q	TCGA-C5-A7UH	CESC	TCGA	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1667
p.R48H	TCGA-CM-6162	COAD	TCGA	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.2222
p.R48H	SIDM00518	Mesothelioma	GDSC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.2222
p.R48H	H290	pleura	COSMIC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.2222
p.S44F	TCGA-DA-A95W	SKCM	TCGA	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation altering degron motif	0.9093
p.R16H	DO8479	COAD	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1111
p.R16H	H290	pleura	COSMIC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1111
p.E38V	DO222877	COCA	ICGC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation altering degron motif	0.6582
p.C11F	DO229028	LICA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.25
p.A2S	DO229031	LICA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation altering degron motif	0.7588
p.E42K	DO218943	LUAD	ICGC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation altering degron motif	0.7022
p.R16C	DO220911	MELA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1111
p.R16C	DO227554	PACA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1111
p.S12F	DO222647	MELA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.2222
p.S12F	DO219479	SKCM	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.2222
p.K29Q	DO46352	OV	ICGC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation blocking ubiquitination signal	0.5556
p.K32N	DO36556	READ	ICGC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.1944
p.E14K	DO219934	SARC	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.1667
p.E53D	DO50291	SKCM	ICGC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.0833
p.K33T	DO47743	STAD	ICGC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.2222
p.S44Y	SIDM01201	Other Blood Cancers	GDSC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation altering degron motif	0.8231
p.S44Y	ACH-002289	Leukemia	CCLE	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation altering degron motif	0.8231
p.S44Y	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation altering degron motif	0.8231
p.R31K	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.1667
p.R31K	ACH-000929	Lung Cancer	CCLE	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.1667
p.R31K	NCI-H2110	lung	COSMIC	LESTPLPS	DEG_SCF_FBW7_1	37:44	Mutation rewiring degron network	0.1667
p.S12Y	NK-92MI	haematopoietic and lymphoid tissue	COSMIC	MNFTPTHT	DEG_SCF_FBW7_1	1:8	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC77

UniProt ID: Q9BR77

Entrez ID: 84318

Protein name: Coiled-coil domain-containing protein 77

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC77 in