DegronMD

Uniprot ID: Q9BR77

Source protein: Coiled-coil domain-containing protein 77

Source gene: CCDC77

Class: DEG_SCF_FBW7_1

Location: 1:8

E3 ligase: FBXW7

DEGRON score: 0.9956

ASA_SCORE: 106.25

COIL: 0.9664

CONS_SCORE: 0.4459

DSS_SCORE: 0.7838

HELIX: 0.0249

FCONS_SCORE: 1.0172

RIG_SCORE: 0.7307

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V17F	TCGA-43-8118	LUSC	TCGA	MNFTPTHT	DEG_SCF_FBW7_1	0.0833
p.V17F	DO45471	LUSC	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.0833
p.N2S	TCGA-BG-A222	UCEC	TCGA	MNFTPTHT	DEG_SCF_FBW7_1	0.5958
p.N2S	DO42977	UCEC	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.5958
p.R14Q	TCGA-C5-A7UH	CESC	TCGA	MNFTPTHT	DEG_SCF_FBW7_1	0.1667
p.R16H	DO8479	COAD	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.1111
p.R16H	H290	pleura	COSMIC	MNFTPTHT	DEG_SCF_FBW7_1	0.1111
p.C11F	DO229028	LICA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.25
p.A2S	DO229031	LICA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.7588
p.R16C	DO220911	MELA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.1111
p.R16C	DO227554	PACA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.1111
p.S12F	DO222647	MELA	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.2222
p.S12F	DO219479	SKCM	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.2222
p.E14K	DO219934	SARC	ICGC	MNFTPTHT	DEG_SCF_FBW7_1	0.1667
p.S12Y	NK-92MI	haematopoietic_and_lymphoid_tissue	COSMIC	MNFTPTHT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BR77	Coiled-coil domain-containing protein 77	DEG_SCF_FBW7_1	1:8	MNFTPTHT	FBXW7	0.9956	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons