DegronMD

Uniprot ID: P0CG40

Source protein: Transcription factor Sp9

Source gene: SP9

Class: DEG_SCF_FBW7_2

Location: 433:439

E3 ligase: FBXW7

DEGRON score: 0.8926

ASA_SCORE: 102.4571

COIL: 0.873

CONS_SCORE: 0.429

DSS_SCORE: 0.6586

HELIX: 0.0909

FCONS_SCORE: 0.8406

RIG_SCORE: 0.6672

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G449S	TCGA-CK-6747	COAD	TCGA	LETPRSE	DEG_SCF_FBW7_2	0.0556
p.G449S	DO10156	COAD	ICGC	LETPRSE	DEG_SCF_FBW7_2	0.0556
p.R437H	DO10140	COAD	ICGC	LETPRSE	DEG_SCF_FBW7_2	0.7133
p.D425N	DO234197	ESAD	ICGC	LETPRSE	DEG_SCF_FBW7_2	0.1111
p.G423D	DO233634	GACA	ICGC	LETPRSE	DEG_SCF_FBW7_2	0.0556
p.S440P	DO228901	LICA	ICGC	LETPRSE	DEG_SCF_FBW7_2	0.75
p.L433P	ACH-001786	Colon/Colorectal Cancer	CCLE	LETPRSE	DEG_SCF_FBW7_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0CG40	Transcription factor Sp9	DEG_SCF_FBW7_2	433:439	LETPRSE	FBXW7	0.8926	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons