DegronMD

Uniprot ID: Q96NW7

Source protein: Leucine-rich repeat-containing protein 7

Source gene: LRRC7

Class: DEG_SCF_FBW7_1

Location: 862:869

E3 ligase: FBXW7

DEGRON score: 0.8831

ASA_SCORE: 89.3875

COIL: 0.9111

CONS_SCORE: 0.5272

DSS_SCORE: 0.7099

HELIX: 0.0373

FCONS_SCORE: 1.0246

RIG_SCORE: 0.642

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P866T	TCGA-22-5473	LUSC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.7031
p.R855S	TCGA-37-3792	LUSC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.1389
p.A857T	TCGA-A5-A0G9	UCEC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.1944
p.A857T	TCGA-AF-6136	READ	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.1944
p.A857T	TCGA-QR-A70N	PCPG	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.1944
p.A857T	TCGA-XK-AAIW	PRAD	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.1944
p.S869I	TCGA-AX-A05Z	UCEC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.7341
p.P872S	TCGA-B5-A1MR	UCEC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.25
p.P870L	TCGA-FW-A3R5	SKCM	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.3056
p.E873K	TCGA-GC-A3I6	BLCA	TCGA	LETTPTTS	DEG_SCF_FBW7_1	0.2222
p.P875S	SIDM01608	Endometrial Carcinoma	GDSC	LETTPTTS	DEG_SCF_FBW7_1	0.2778
p.T872I	SIDM01442	Glioma	GDSC	LETTPTTS	DEG_SCF_FBW7_1	0.25
p.T867I	ACH-000807	Brain Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	0.5966
p.I878M	ACH-000984	Endometrial/Uterine Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	0.0833
p.P870S	ACH-000990	Endometrial/Uterine Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	0.3056
p.P872L	ACH-002027	Endometrial/Uterine Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NW7	Leucine-rich repeat-containing protein 7	DEG_SCF_FBW7_1	862:869	LETTPTTS	FBXW7	0.8831	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons