DegronMD - Q96NW7(LRRC7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R559S	TCGA-14-0813	GBM	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.0556
p.R559S	TCGA-14-0813	GBM	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.P866T	TCGA-22-5473	LUSC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.7031
p.R855S	TCGA-37-3792	LUSC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1389
p.P573R	TCGA-43-5668	LUSC	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.6401
p.T542N	TCGA-4Z-AA7S	BLCA	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.N564S	TCGA-55-7727	LUAD	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1944
p.V583F	TCGA-55-8508	LUAD	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.0833
p.P543S	TCGA-78-7147	LUAD	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1944
p.A857T	TCGA-A5-A0G9	UCEC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1944
p.A857T	TCGA-AF-6136	READ	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1944
p.A857T	TCGA-QR-A70N	PCPG	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1944
p.A857T	TCGA-XK-AAIW	PRAD	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.1944
p.S869I	TCGA-AX-A05Z	UCEC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.7341
p.C541R	TCGA-AX-A2HD	UCEC	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.P872S	TCGA-B5-A1MR	UCEC	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.25
p.P545Q	TCGA-D3-A2JP	SKCM	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.R567Q	TCGA-D3-A51T	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.R567Q	TCGA-EE-A2M6	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.R567Q	TCGA-FR-A8YC	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.R567Q	TCGA-GN-A266	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.R567Q	TCGA-YD-A9TA	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.R567Q	ACH-000881	Skin Cancer	CCLE	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.R567Q	MEL-JUSO	skin	COSMIC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.T542A	TCGA-DI-A1BU	UCEC	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.T542A	DND-41	haematopoietic and lymphoid tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.T542A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.T542A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.A547T	TCGA-E5-A4U1	BLCA	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.P870L	TCGA-FW-A3R5	SKCM	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.3056
p.E873K	TCGA-GC-A3I6	BLCA	TCGA	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.2222
p.L544F	TCGA-RD-A8MW	STAD	TCGA	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.V580L	TCGA-S9-A6UA	LGG	TCGA	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1667
p.T547N	DO218982	BLCA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.A552T	DO44061	BLCA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7139
p.R569T	DO219018	BLCA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7876
p.K542N	DO222737	COCA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1667
p.A553S	DO233620	GACA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.E544Q	DO233828	GACA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.R564S	DO13947	GBM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1944
p.E563Q	DO15286	HNSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1667
p.A564T	DO228374	LICA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1944
p.G548V	DO229019	LICA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7532
p.G548V	DO47767	STAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7532
p.R572L	DO229015	LICA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.8428
p.M545I	DO229035	LICA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.25
p.L549F	DO229045	LICA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.6981
p.L549F	DO50134	STAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.6981
p.L583V	DO229052	LICA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.0833
p.I562M	DO52290	LIHC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1389
p.I562M	DO52290	LIHC	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.N569S	DO24297	LUAD	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7069
p.P548S	DO24527	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.6752
p.A552E	DO23850	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7701
p.E544G	DO23846	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2222
p.D553Y	DO45318	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.T539N	DO24970	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0833
p.Q540K	DO230993	LUSC	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.P578R	DO26608	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2222
p.R569K	DO45475	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7237
p.A572T	DO219131	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7139
p.I562V	DO219178	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1389
p.I562V	DO219178	LUSC	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.0556
p.R572Q	DO222514	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	DO37432	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	DO50301	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	DO37976	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	DO47389	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	DO219503	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	SIDM00336	Melanoma	GDSC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.R572Q	MEL-JUSO	skin	COSMIC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7329
p.P584L	DO222632	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.0556
p.P584L	DO37571	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.0556
p.V566A	DO222702	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation substituting flanking lysine	0.3611
p.P559L	DO222837	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.0556
p.P559L	DO222837	MELA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.P576L	DO222843	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.2778
p.V541L	DO47000	RECA	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1389
p.P550Q	DO47407	SKCM	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation altering degron motif	0.7035
p.L580I	DO47683	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1667
p.M582V	DO47829	STAD	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1111
p.N579S	DO47953	STAD	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1944
p.T547A	DO42023	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.T547A	DND-41	haematopoietic and lymphoid tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.T547A	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.T547A	Daudi	haematopoietic and lymphoid tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.3056
p.R566W	DO43186	UCEC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation substituting flanking lysine	0.3611
p.M582I	DO41638	UCEC	ICGC	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation rewiring degron network	0.1111
p.C546R	DO42608	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.2778
p.P540L	DO41361	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	548:552	Mutation rewiring degron network	0.1111
p.P875S	SIDM01608	Endometrial Carcinoma	GDSC	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation substituting flanking lysine	0.2778
p.T872I	SIDM01442	Glioma	GDSC	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.25
p.T867I	ACH-000807	Brain Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation altering degron motif	0.5966
p.I878M	ACH-000984	Endometrial/Uterine Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.0833
p.P870S	ACH-000990	Endometrial/Uterine Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.3056
p.P571A	ACH-001119	Lymphoma	CCLE	PTPYPE	DEG_SCF_FBW7_2	569:574	Mutation altering degron motif	0.7503
p.P872L	ACH-002027	Endometrial/Uterine Cancer	CCLE	LETTPTTS	DEG_SCF_FBW7_1	862:869	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRRC7

UniProt ID: Q96NW7

Entrez ID:

Protein name: Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRRC7 in