DegronMD

Uniprot ID: Q96NW7

Source protein: Leucine-rich repeat-containing protein 7

Source gene: LRRC7

Class: DEG_SPOP_SBC_1

Location: 548:552

E3 ligase: SPOP

DEGRON score: 0.6999

ASA_SCORE: 87.08

COIL: 0.8266

CONS_SCORE: 0.4295

DSS_SCORE: 0.4274

HELIX: 0.0538

FCONS_SCORE: 0.9234

RIG_SCORE: 0.7263

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R559S	TCGA-14-0813	GBM	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1389
p.T542N	TCGA-4Z-AA7S	BLCA	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1667
p.P543S	TCGA-78-7147	LUAD	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1944
p.C541R	TCGA-AX-A2HD	UCEC	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1389
p.P545Q	TCGA-D3-A2JP	SKCM	TCGA	AQSTT	DEG_SPOP_SBC_1	0.25
p.T542A	TCGA-DI-A1BU	UCEC	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1667
p.T542A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.1667
p.T542A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.1667
p.T542A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.1667
p.A547T	TCGA-E5-A4U1	BLCA	TCGA	AQSTT	DEG_SPOP_SBC_1	0.3056
p.L544F	TCGA-RD-A8MW	STAD	TCGA	AQSTT	DEG_SPOP_SBC_1	0.2222
p.T547N	DO218982	BLCA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.A552T	DO44061	BLCA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.7139
p.K542N	DO222737	COCA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1667
p.A553S	DO233620	GACA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.E544Q	DO233828	GACA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.2222
p.G548V	DO229019	LICA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.7532
p.G548V	DO47767	STAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.7532
p.M545I	DO229035	LICA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.25
p.L549F	DO229045	LICA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.6981
p.L549F	DO50134	STAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.6981
p.I562M	DO52290	LIHC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.0556
p.P548S	DO24527	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.6752
p.A552E	DO23850	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.7701
p.E544G	DO23846	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.2222
p.D553Y	DO45318	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.T539N	DO24970	LUAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.0833
p.Q540K	DO230993	LUSC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1111
p.I562V	DO219178	LUSC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.0556
p.P559L	DO222837	MELA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1389
p.V541L	DO47000	RECA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1389
p.P550Q	DO47407	SKCM	ICGC	AQSTT	DEG_SPOP_SBC_1	0.7035
p.T547A	DO42023	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.T547A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.T547A	OCI-AML5	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.T547A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.C546R	DO42608	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.2778
p.P540L	DO41361	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1321:1325	AQSTT	SPOP	0.8673	More...
Q96NW7	Leucine-rich repeat-containing protein 7	DEG_SPOP_SBC_1	548:552	AQSTT	SPOP	0.6999	More...
Q8TBR5	Putative uncharacterized protein CIRBP-AS1	DEG_SPOP_SBC_1	66:70	AQSTT	SPOP	0.7078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: AQSTT

Degron related mutations and impact score

Drug responses associated with LRRC7 mutations

All proteins holding degron of AQSTT