DegronMD: protein-targeted degradation, mutation and drug response to degrons
Home
(current)
Browse
Proteins/Degrons
Mutations
Drug response
Network-rewiring
Drug resistance
Search
Tutorial
Download
Contact
Links
BSML
CPH
CGC
Degron:
AQSTT
Uniprot ID:
Q8TBR5
Source protein:
Putative uncharacterized protein CIRBP-AS1
Source gene:
CIRBP-AS1
Class:
DEG_SPOP_SBC_1
Location:
66:70
E3 ligase:
SPOP
DEGRON score:
0.7078
ASA_SCORE:
64.46
COIL:
0.4728
CONS_SCORE:
0
DSS_SCORE:
0.4077
HELIX:
0.2722
FCONS_SCORE:
0
RIG_SCORE:
0.8274
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with CIRBP-AS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of AQSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q6W4X9
Mucin-6
DEG_SPOP_SBC_1
1321:1325
AQSTT
SPOP
0.8673
More...
Q96NW7
Leucine-rich repeat-containing protein 7
DEG_SPOP_SBC_1
548:552
AQSTT
SPOP
0.6999
More...
Q8TBR5
Putative uncharacterized protein CIRBP-AS1
DEG_SPOP_SBC_1
66:70
AQSTT
SPOP
0.7078
More...