DegronMD

Uniprot ID: Q6W4X9

Source protein: Mucin-6

Source gene: MUC6

Class: DEG_SPOP_SBC_1

Location: 1321:1325

E3 ligase: SPOP

DEGRON score: 0.8673

ASA_SCORE: 86.26

COIL: 0.8228

CONS_SCORE: 0.3462

DSS_SCORE: 0.687

HELIX: 0.0542

FCONS_SCORE: 1.1999

RIG_SCORE: 0.6669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1315Q	TCGA-22-5483	LUSC	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1667
p.P1315Q	DO26614	LUSC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1667
p.T1330I	TCGA-AX-A2HD	UCEC	TCGA	AQSTT	DEG_SPOP_SBC_1	0.1944
p.T1330I	DO42608	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.1944
p.T1318M	TCGA-AZ-6598	COAD	TCGA	AQSTT	DEG_SPOP_SBC_1	0.25
p.T1318M	DO10276	COAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.25
p.T1317M	TCGA-B5-A3FA	UCEC	TCGA	AQSTT	DEG_SPOP_SBC_1	0.2222
p.T1317M	DO52402	UCEC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.2222
p.Q1322E	TCGA-DK-AA6L	BLCA	TCGA	AQSTT	DEG_SPOP_SBC_1	0.5633
p.Q1322E	DO219002	BLCA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.5633
p.S1323F	TCGA-EA-A439	CESC	TCGA	AQSTT	DEG_SPOP_SBC_1	0.7982
p.S1323F	DO44297	CESC	ICGC	AQSTT	DEG_SPOP_SBC_1	0.7982
p.S1319A	DO234213	ESAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.2778
p.Q1322H	DO234213	ESAD	ICGC	AQSTT	DEG_SPOP_SBC_1	0.647
p.R1326W	DO218693	GACA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.R1326W	DO233272	GACA	ICGC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.R1326Q	SIDM00545	Melanoma	GDSC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.R1326Q	ACH-000987	Skin Cancer	CCLE	AQSTT	DEG_SPOP_SBC_1	0.3056
p.R1326Q	Mewo	skin	COSMIC	AQSTT	DEG_SPOP_SBC_1	0.3056
p.T1312P	ACH-000846	Head and Neck Cancer	CCLE	AQSTT	DEG_SPOP_SBC_1	0.0833
p.T1312P	ACH-000979	Prostate Cancer	CCLE	AQSTT	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6W4X9	Mucin-6	DEG_SPOP_SBC_1	1321:1325	AQSTT	SPOP	0.8673	More...
Q96NW7	Leucine-rich repeat-containing protein 7	DEG_SPOP_SBC_1	548:552	AQSTT	SPOP	0.6999	More...
Q8TBR5	Putative uncharacterized protein CIRBP-AS1	DEG_SPOP_SBC_1	66:70	AQSTT	SPOP	0.7078	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons