DegronMD

Uniprot ID: Q96NW7

Source protein: Leucine-rich repeat-containing protein 7

Source gene: LRRC7

Class: DEG_SCF_FBW7_2

Location: 569:574

E3 ligase: FBXW7

DEGRON score: 0.9993

ASA_SCORE: 88.2

COIL: 0.852

CONS_SCORE: 0.5338

DSS_SCORE: 0.4294

HELIX: 0.1398

FCONS_SCORE: 1.0326

RIG_SCORE: 0.7473

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R559S	TCGA-14-0813	GBM	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.0556
p.P573R	TCGA-43-5668	LUSC	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.6401
p.N564S	TCGA-55-7727	LUAD	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.1944
p.V583F	TCGA-55-8508	LUAD	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.0833
p.R567Q	TCGA-D3-A51T	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.R567Q	TCGA-EE-A2M6	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.R567Q	TCGA-FR-A8YC	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.R567Q	TCGA-GN-A266	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.R567Q	TCGA-YD-A9TA	SKCM	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.R567Q	ACH-000881	Skin Cancer	CCLE	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.R567Q	MEL-JUSO	skin	COSMIC	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.V580L	TCGA-S9-A6UA	LGG	TCGA	PTPYPE	DEG_SCF_FBW7_2	0.1667
p.R569T	DO219018	BLCA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7876
p.R564S	DO13947	GBM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1944
p.E563Q	DO15286	HNSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1667
p.A564T	DO228374	LICA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1944
p.R572L	DO229015	LICA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.8428
p.L583V	DO229052	LICA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.0833
p.I562M	DO52290	LIHC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1389
p.N569S	DO24297	LUAD	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7069
p.P578R	DO26608	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.2222
p.R569K	DO45475	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7237
p.A572T	DO219131	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7139
p.I562V	DO219178	LUSC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1389
p.R572Q	DO222514	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	DO37432	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	DO50301	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	DO37976	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	DO47389	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	DO219503	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	SIDM00336	Melanoma	GDSC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.R572Q	MEL-JUSO	skin	COSMIC	PTPYPE	DEG_SCF_FBW7_2	0.7329
p.P584L	DO222632	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.0556
p.P584L	DO37571	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.0556
p.V566A	DO222702	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.3611
p.P559L	DO222837	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.0556
p.P576L	DO222843	MELA	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.2778
p.L580I	DO47683	SKCM	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1667
p.M582V	DO47829	STAD	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1111
p.N579S	DO47953	STAD	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1944
p.R566W	DO43186	UCEC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.3611
p.M582I	DO41638	UCEC	ICGC	PTPYPE	DEG_SCF_FBW7_2	0.1111
p.P571A	ACH-001119	Lymphoma	CCLE	PTPYPE	DEG_SCF_FBW7_2	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PTPYPE

Degron related mutations and impact score

Drug responses associated with LRRC7 mutations

All proteins holding degron of PTPYPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96NW7	Leucine-rich repeat-containing protein 7	DEG_SCF_FBW7_2	569:574	PTPYPE	FBXW7	0.9993	More...