DegronMD

Uniprot ID: Q92545

Source protein: Transmembrane protein 131

Source gene: TMEM131

Class: LIG_APCC_ABBA_1

Location: 1366:1371

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9422

ASA_SCORE: 99.15

COIL: 0.6177

CONS_SCORE: 0.33

DSS_SCORE: 0.7186

HELIX: 0.3573

FCONS_SCORE: 1.0106

RIG_SCORE: 0.6884

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1374T	TCGA-G7-6797	KIRP	TCGA	LEVFTE	LIG_APCC_ABBA_1	0.25
p.P1374T	DO20917	KIRP	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.25
p.D1359N	DO229010	COCA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	DO229013	COCA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	DO229016	COCA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	DO229003	COCA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	DO230937	LUSC	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	DO231149	LUSC	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00425	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00321	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00194	Colorectal Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00557	Neuroblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00993	Plasma Cell Myeloma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00615	Hepatocellular Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00572	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00075	Non-Cancerous	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00064	Hepatocellular Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00352	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00535	Chondrosarcoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00600	Thyroid Gland Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00291	Melanoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00607	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00315	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00362	Burkitt's Lymphoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00193	Colorectal Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01144	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00465	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00293	Small Cell Lung Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01194	Hepatocellular Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00466	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00040	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01181	Hepatocellular Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00238	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01032	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00287	B-Lymphoblastic Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00235	Kidney Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00358	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00486	Squamous Cell Lung Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01172	Acute Myeloid Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00587	Biliary Tract Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01180	Hepatocellular Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00488	Colorectal Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00242	Osteosarcoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00502	B-Lymphoblastic Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00247	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01210	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00018	Acute Myeloid Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00616	Hepatocellular Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01061	Oral Cavity Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00271	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00566	Oral Cavity Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00380	Acute Myeloid Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00361	Non-Small Cell Lung Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00045	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00316	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00349	Esophageal Squamous Cell Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00274	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00083	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00302	Other Solid Cancers	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01018	Hodgkin's Lymphoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00243	Other Solid Cancers	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00381	Cervical Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00531	Pancreatic Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00192	Colorectal Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01735	Biliary Tract Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01617	Endometrial Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00168	Head and Neck Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01470	Acute Myeloid Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01412	Oral Cavity Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01368	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01578	Bladder Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00008	Ovarian Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01611	Endometrial Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00158	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01573	Plasma Cell Myeloma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01779	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01494	Glioblastoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01691	Chronic Myelogenous Leukemia	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01433	Kidney Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01454	Kidney Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01321	Pancreatic Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00171	Colorectal Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM00162	Biliary Tract Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01343	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.D1359N	SIDM01443	Gastric Carcinoma	GDSC	LEVFTE	LIG_APCC_ABBA_1	0.1389
p.H1360Q	DO228900	LICA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.1667
p.A1365D	DO229035	LICA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.3056
p.V1368A	DO50886	LICA	ICGC	LEVFTE	LIG_APCC_ABBA_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LEVFTE

Degron related mutations and impact score

Drug responses associated with TMEM131 mutations

All proteins holding degron of LEVFTE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92545	Transmembrane protein 131	LIG_APCC_ABBA_1	1366:1371	LEVFTE	APC,CDC20,FZR1	0.9422	More...