DegronMD

Uniprot ID: Q9BVC4

Source protein: Target of rapamycin complex subunit LST8

Source gene: MLST8

Class: DEG_SCF_FBW7_1

Location: 48:55

E3 ligase: FBXW7

DEGRON score: 0.5273

ASA_SCORE: 42.9125

COIL: 0.616

CONS_SCORE: 0.6356

DSS_SCORE: 0.3441

HELIX: 0.0075

FCONS_SCORE: 0.9832

RIG_SCORE: 0.8015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R54H	TCGA-AU-6004	COAD	TCGA	LEVTPDRS	DEG_SCF_FBW7_1	0.7133
p.R54H	DO7780	COAD	ICGC	LEVTPDRS	DEG_SCF_FBW7_1	0.7133
p.E49D	TCGA-EE-A20F	SKCM	TCGA	LEVTPDRS	DEG_SCF_FBW7_1	0.5647
p.E49D	DO37961	SKCM	ICGC	LEVTPDRS	DEG_SCF_FBW7_1	0.5647
p.A60S	DO228948	LICA	ICGC	LEVTPDRS	DEG_SCF_FBW7_1	0.1944
p.V45L	DO229022	LICA	ICGC	LEVTPDRS	DEG_SCF_FBW7_1	0.25
p.P52A	SIDM00980	Gastric Carcinoma	GDSC	LEVTPDRS	DEG_SCF_FBW7_1	0.7503
p.P52A	ACH-000948	Gastric Cancer	CCLE	LEVTPDRS	DEG_SCF_FBW7_1	0.7503
p.P52A	23132-87	stomach	COSMIC	LEVTPDRS	DEG_SCF_FBW7_1	0.7503
p.P52L	SIDM01322	Oral Cavity Carcinoma	GDSC	LEVTPDRS	DEG_SCF_FBW7_1	0.7582
p.P52L	ACH-000735	Head and Neck Cancer	CCLE	LEVTPDRS	DEG_SCF_FBW7_1	0.7582
p.P51A	23132-87	stomach	COSMIC	LEVTPDRS	DEG_SCF_FBW7_1	0.7503

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BVC4	Target of rapamycin complex subunit LST8	DEG_SCF_FBW7_1	48:55	LEVTPDRS	FBXW7	0.5273	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons