DegronMD

Uniprot ID: Q9NS15

Source protein: Latent-transforming growth factor beta-binding protein 3

Source gene: LTBP3

Class: LIG_APCC_ABBA_1

Location: 480:485

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9729

ASA_SCORE: 69.8333

COIL: 0.7538

CONS_SCORE: 0.5556

DSS_SCORE: 0.7535

HELIX: 0.1147

FCONS_SCORE: 1.0566

RIG_SCORE: 0.6569

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E475K	TCGA-60-2714	LUSC	TCGA	LFLHPD	LIG_APCC_ABBA_1	0.1944
p.E475K	DO26530	LUSC	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.1944
p.Q473K	DO228948	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.1389
p.A491D	DO229026	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.1667
p.D485E	DO229035	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.5647
p.T471N	DO229041	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.0833
p.P487T	DO229006	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.2778
p.H483Y	DO228371	MALY	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.6118
p.H483Y	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	LFLHPD	LIG_APCC_ABBA_1	0.6118
p.H483Y	ACH-000315	Lymphoma	CCLE	LFLHPD	LIG_APCC_ABBA_1	0.6118
p.H483Y	KARPAS-422	haematopoietic_and_lymphoid_tissue	COSMIC	LFLHPD	LIG_APCC_ABBA_1	0.6118
p.R475G	DO233295	NACA	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.1944
p.F478I	DO46593	OV	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.2778
p.N471T	DO219253	PRAD	ICGC	LFLHPD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS15	Latent-transforming growth factor beta-binding protein 3	LIG_APCC_ABBA_1	480:485	LFLHPD	APC,CDC20,FZR1	0.9729	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons