DegronMD - Q9NS15(LTBP3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E475K	TCGA-60-2714	LUSC	TCGA	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1944
p.E475K	DO26530	LUSC	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1944
p.P556S	TCGA-DD-A4NJ	LIHC	TCGA	MRWFLPDLP	DEG_APCC_DBOX_1	551:559	Mutation altering degron motif	0.5641
p.P556S	DO44873	LIHC	ICGC	MRWFLPDLP	DEG_APCC_DBOX_1	551:559	Mutation altering degron motif	0.5641
p.Q473K	DO228948	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1389
p.S563R	DO228978	LICA	ICGC	MRWFLPDLP	DEG_APCC_DBOX_1	551:559	Mutation rewiring degron network	0.2222
p.S563R	DO229027	LICA	ICGC	MRWFLPDLP	DEG_APCC_DBOX_1	551:559	Mutation rewiring degron network	0.2222
p.A491D	DO229026	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1667
p.D485E	DO229035	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.5647
p.T471N	DO229041	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.0833
p.P487T	DO229006	LICA	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.H483Y	DO228371	MALY	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6118
p.H483Y	SIDM01008	B-Cell Non-Hodgkin's Lymphoma	GDSC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6118
p.H483Y	ACH-000315	Lymphoma	CCLE	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6118
p.H483Y	KARPAS-422	haematopoietic and lymphoid tissue	COSMIC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation altering degron motif	0.6118
p.R475G	DO233295	NACA	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.1944
p.F478I	DO46593	OV	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.2778
p.N471T	DO219253	PRAD	ICGC	LFLHPD	LIG_APCC_ABBA_1	480:485	Mutation rewiring degron network	0.0833
p.E541D	SIDM02015	Colorectal Carcinoma	GDSC	MRWFLPDLP	DEG_APCC_DBOX_1	551:559	Mutation rewiring degron network	0.0556
p.P549A	ACH-000437	Brain Cancer	CCLE	MRWFLPDLP	DEG_APCC_DBOX_1	551:559	Mutation rewiring degron network	0.2778

Kaplan plot for LTBP3 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LTBP3

UniProt ID: Q9NS15

Entrez ID: 4054

Protein name: Latent-transforming growth factor beta-binding protein 3 (LTBP-3)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for LTBP3 in