DegronMD

Uniprot ID: Q9NS15

Source protein: Latent-transforming growth factor beta-binding protein 3

Source gene: LTBP3

Class: DEG_APCC_DBOX_1

Location: 551:559

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9444

ASA_SCORE: 78.0778

COIL: 0.8073

CONS_SCORE: 0.4055

DSS_SCORE: 0.533

HELIX: 0.0977

FCONS_SCORE: 0.8244

RIG_SCORE: 0.7401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P556S	TCGA-DD-A4NJ	LIHC	TCGA	MRWFLPDLP	DEG_APCC_DBOX_1	0.5641
p.P556S	DO44873	LIHC	ICGC	MRWFLPDLP	DEG_APCC_DBOX_1	0.5641
p.S563R	DO228978	LICA	ICGC	MRWFLPDLP	DEG_APCC_DBOX_1	0.2222
p.S563R	DO229027	LICA	ICGC	MRWFLPDLP	DEG_APCC_DBOX_1	0.2222
p.E541D	SIDM02015	Colorectal Carcinoma	GDSC	MRWFLPDLP	DEG_APCC_DBOX_1	0.0556
p.P549A	ACH-000437	Brain Cancer	CCLE	MRWFLPDLP	DEG_APCC_DBOX_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NS15	Latent-transforming growth factor beta-binding protein 3	DEG_APCC_DBOX_1	551:559	MRWFLPDLP	APC,CDC20,FZR1	0.9444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons