DegronMD

Uniprot ID: Q96PJ5

Source protein: Fc receptor-like protein 4

Source gene: FCRL4

Class: LIG_APCC_ABBA_1

Location: 189:194

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9962

ASA_SCORE: 74.8333

COIL: 0.7387

CONS_SCORE: 0.5742

DSS_SCORE: 0.4228

HELIX: 0.013

FCONS_SCORE: 1.0364

RIG_SCORE: 0.7783

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L189Q	TCGA-14-1451	GBM	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.7765
p.L189Q	DO13384	GBM	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.7765
p.P193S	TCGA-AX-A06F	UCEC	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.5641
p.P193S	DO41752	UCEC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.5641
p.L189I	TCGA-B5-A11E	UCEC	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.6063
p.L189I	DO41644	UCEC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.6063
p.E194D	TCGA-CV-7254	HNSC	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.5647
p.E194D	DO14168	HNSC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.5647
p.K185R	TCGA-CZ-4865	KIRC	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.3333
p.K185R	DO16741	KIRC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.3333
p.P191S	TCGA-D8-A1JG	BRCA	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.6752
p.P191S	DO1256	BRCA	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.6752
p.E194Q	TCGA-DI-A1NO	UCEC	TCGA	LFPHPE	LIG_APCC_ABBA_1	0.6744
p.E194Q	DO41662	UCEC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.6744
p.E204D	DO234348	ESAD	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.0556
p.K196N	DO234378	ESAD	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.2778
p.P193Q	DO229037	LICA	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.5924
p.S200C	DO230968	LUSC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.1667
p.S200C	DO224621	LUSC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.1667
p.T198I	DO231165	LUSC	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.2222
p.I186T	DO229216	THCA	ICGC	LFPHPE	LIG_APCC_ABBA_1	0.25
p.I184L	SIDM01611	Endometrial Carcinoma	GDSC	LFPHPE	LIG_APCC_ABBA_1	0.1944
p.I184L	ACH-000996	Endometrial/Uterine Cancer	CCLE	LFPHPE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PJ5	Fc receptor-like protein 4	LIG_APCC_ABBA_1	189:194	LFPHPE	APC,CDC20,FZR1	0.9962	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons