DegronMD

Uniprot ID: Q15306

Source protein: Interferon regulatory factor 4

Source gene: IRF4

Class: LIG_APCC_ABBA_1

Location: 291:296

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9914

ASA_SCORE: 74.2167

COIL: 0.8518

CONS_SCORE: 0.5415

DSS_SCORE: 0.4292

HELIX: 0.0327

FCONS_SCORE: 1.1315

RIG_SCORE: 0.8005

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P293H	TCGA-28-5211	GBM	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.7694
p.P293H	DO11016	GBM	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.7694
p.D297Y	TCGA-69-7765	LUAD	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.3056
p.D297Y	DO23580	LUAD	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.3056
p.E305D	TCGA-95-7947	LUAD	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.0833
p.E305D	DO26404	LUAD	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.0833
p.A284V	TCGA-BG-A222	UCEC	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.1389
p.A284V	DO42977	UCEC	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.1389
p.D297N	TCGA-DA-A3F8	SKCM	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.3056
p.D297N	DO37418	SKCM	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.3056
p.P293S	TCGA-EB-A431	SKCM	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.6752
p.P293S	DO37671	SKCM	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.6752
p.K306N	TCGA-V5-A7RB	ESCA	TCGA	LFPYPE	LIG_APCC_ABBA_1	0.5
p.K306N	DO7214	CLLE	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.5
p.K306N	SIDM00683	Prostate Carcinoma	GDSC	LFPYPE	LIG_APCC_ABBA_1	0.5
p.K306N	ACH-000977	lymph_node	CCLE	LFPYPE	LIG_APCC_ABBA_1	0.5
p.K306N	LNCaP-Clone-FGC	prostate	COSMIC	LFPYPE	LIG_APCC_ABBA_1	0.5
p.G299S	DO217850	BTCA	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.25
p.I304T	DO231672	LINC	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.1111
p.K302T	DO222843	MELA	ICGC	LFPYPE	LIG_APCC_ABBA_1	0.2778
p.G299D	SIDM00217	Colorectal Carcinoma	GDSC	LFPYPE	LIG_APCC_ABBA_1	0.25
p.G299D	ACH-000999	Colon/Colorectal Cancer	CCLE	LFPYPE	LIG_APCC_ABBA_1	0.25
p.G299D	SNU-1040	large_intestine	COSMIC	LFPYPE	LIG_APCC_ABBA_1	0.25
p.L291R	SIDM01608	Endometrial Carcinoma	GDSC	LFPYPE	LIG_APCC_ABBA_1	0.8428
p.L291R	ACH-000990	Endometrial/Uterine Cancer	CCLE	LFPYPE	LIG_APCC_ABBA_1	0.8428

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15306	Interferon regulatory factor 4	LIG_APCC_ABBA_1	291:296	LFPYPE	APC,CDC20,FZR1	0.9914	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons