DegronMD - Q15306(IRF4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P293H	TCGA-28-5211	GBM	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation altering degron motif	0.7694
p.P293H	DO11016	GBM	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation altering degron motif	0.7694
p.V166L	TCGA-55-A490	LUAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1667
p.V166L	DO24596	LUAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1667
p.P151T	TCGA-55-A4DG	LUAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.25
p.P151T	DO26337	LUAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.25
p.D297Y	TCGA-69-7765	LUAD	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.3056
p.D297Y	DO23580	LUAD	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.3056
p.E305D	TCGA-95-7947	LUAD	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.0833
p.E305D	DO26404	LUAD	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.0833
p.P144Q	TCGA-B5-A5OC	UCEC	TCGA	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.0556
p.P144Q	DO52405	UCEC	ICGC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.0556
p.A284V	TCGA-BG-A222	UCEC	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.1389
p.A284V	DO42977	UCEC	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.1389
p.D297N	TCGA-DA-A3F8	SKCM	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.3056
p.D297N	DO37418	SKCM	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.3056
p.P293S	TCGA-EB-A431	SKCM	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation altering degron motif	0.6752
p.P293S	DO37671	SKCM	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation altering degron motif	0.6752
p.T156M	TCGA-R5-A805	STAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation altering degron motif	0.7423
p.T156M	DO222346	STAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation altering degron motif	0.7423
p.K306N	TCGA-V5-A7RB	ESCA	TCGA	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation blocking ubiquitination signal	0.5
p.K306N	DO7214	CLLE	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation blocking ubiquitination signal	0.5
p.K306N	SIDM00683	Prostate Carcinoma	GDSC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation blocking ubiquitination signal	0.5
p.K306N	ACH-000977	lymph node	CCLE	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation blocking ubiquitination signal	0.5
p.K306N	LNCaP-Clone-FGC	prostate	COSMIC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation blocking ubiquitination signal	0.5
p.P157A	DO227629	BRCA	ICGC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation altering degron motif	0.7503
p.G299S	DO217850	BTCA	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.25
p.I304T	DO231672	LINC	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.1111
p.P159R	DO231040	LUSC	ICGC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation altering degron motif	0.6401
p.K302T	DO222843	MELA	ICGC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation substituting flanking lysine	0.2778
p.S149N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00967	Ovarian Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00393	Gastric Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00087	Plasma Cell Myeloma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00846	Cervical Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00633	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM01112	Osteosarcoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00694	Other Solid Cancers	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00878	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00971	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00032	Bladder Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00720	Mesothelioma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00673	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM00808	Burkitt's Lymphoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM01686	Chronic Myelogenous Leukemia	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM01664	Prostate Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.S149N	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1944
p.G299D	SIDM00217	Colorectal Carcinoma	GDSC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.25
p.G299D	ACH-000999	Colon/Colorectal Cancer	CCLE	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.25
p.G299D	SNU-1040	large intestine	COSMIC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation rewiring degron network	0.25
p.L291R	SIDM01608	Endometrial Carcinoma	GDSC	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation altering degron motif	0.8428
p.L291R	ACH-000990	Endometrial/Uterine Cancer	CCLE	LFPYPE	LIG_APCC_ABBA_1	291:296	Mutation altering degron motif	0.8428
p.S147P	ACH-000928	Endometrial/Uterine Cancer	CCLE	MTTPYPS	DEG_SCF_FBW7_1	154:160	Mutation rewiring degron network	0.1389

Kaplan plot for IRF4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IRF4

UniProt ID: Q15306

Entrez ID: 3662

Protein name: Interferon regulatory factor 4 (IRF-4) (Lymphocyte-specific interferon regulatory factor) (LSIRF) (Multiple myeloma oncogene 1) (NF-EM5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IRF4 in