DegronMD

Uniprot ID: Q15306

Source protein: Interferon regulatory factor 4

Source gene: IRF4

Class: DEG_SCF_FBW7_1

Location: 154:160

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 77.2714

COIL: 0.9087

CONS_SCORE: 0.4655

DSS_SCORE: 0.5138

HELIX: 0.0374

FCONS_SCORE: 0.9913

RIG_SCORE: 0.684

Degron related mutations and impact score

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P157A	DO227629	BRCA	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.7503
p.T156M	TCGA-R5-A805	STAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.7423
p.T156M	DO222346	STAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.7423
p.P159R	DO231040	LUSC	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.6401
p.P151T	TCGA-55-A4DG	LUAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.25
p.P151T	DO26337	LUAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.25
p.S149N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00967	Ovarian Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00393	Gastric Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00087	Plasma Cell Myeloma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00846	Cervical Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00633	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01112	Osteosarcoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00694	Other Solid Cancers	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00878	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00971	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00032	Bladder Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00720	Mesothelioma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00673	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00808	Burkitt's Lymphoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01686	Chronic Myelogenous Leukemia	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01664	Prostate Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.V166L	TCGA-55-A490	LUAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.1667
p.V166L	DO24596	LUAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.1667

Showing 1 to 25 of 28 entries

Previous1 2Next

Drug responses associated with IRF4 mutations

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

All proteins holding degron of MTTPYPS

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15306	Interferon regulatory factor 4	DEG_SCF_FBW7_1	154:160	MTTPYPS	FBXW7	0.9626	More...

Showing 1 to 1 of 1 entries

Previous1Next

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTTPYPS

Degron related mutations and impact score

Drug responses associated with IRF4 mutations

All proteins holding degron of MTTPYPS