DegronMD

Uniprot ID: Q15306

Source protein: Interferon regulatory factor 4

Source gene: IRF4

Class: DEG_SCF_FBW7_1

Location: 154:160

E3 ligase: FBXW7

DEGRON score: 0.9626

ASA_SCORE: 77.2714

COIL: 0.9087

CONS_SCORE: 0.4655

DSS_SCORE: 0.5138

HELIX: 0.0374

FCONS_SCORE: 0.9913

RIG_SCORE: 0.684

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V166L	TCGA-55-A490	LUAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.1667
p.V166L	DO24596	LUAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.1667
p.P151T	TCGA-55-A4DG	LUAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.25
p.P151T	DO26337	LUAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.25
p.P144Q	TCGA-B5-A5OC	UCEC	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.0556
p.P144Q	DO52405	UCEC	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.0556
p.T156M	TCGA-R5-A805	STAD	TCGA	MTTPYPS	DEG_SCF_FBW7_1	0.7423
p.T156M	DO222346	STAD	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.7423
p.P157A	DO227629	BRCA	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.7503
p.P159R	DO231040	LUSC	ICGC	MTTPYPS	DEG_SCF_FBW7_1	0.6401
p.S149N	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00967	Ovarian Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00393	Gastric Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00087	Plasma Cell Myeloma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00846	Cervical Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00633	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01112	Osteosarcoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00694	Other Solid Cancers	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00878	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00971	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00032	Bladder Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00720	Mesothelioma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00673	Breast Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM00808	Burkitt's Lymphoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01686	Chronic Myelogenous Leukemia	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01664	Prostate Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S149N	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	MTTPYPS	DEG_SCF_FBW7_1	0.1944
p.S147P	ACH-000928	Endometrial/Uterine Cancer	CCLE	MTTPYPS	DEG_SCF_FBW7_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTTPYPS

Degron related mutations and impact score

Drug responses associated with IRF4 mutations

All proteins holding degron of MTTPYPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15306	Interferon regulatory factor 4	DEG_SCF_FBW7_1	154:160	MTTPYPS	FBXW7	0.9626	More...