DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 12001:12007

E3 ligase: FBXW7

DEGRON score: 0.9253

ASA_SCORE: 92.5714

COIL: 0.8109

CONS_SCORE: 0

DSS_SCORE: 0.3773

HELIX: 0.0167

FCONS_SCORE: 0

RIG_SCORE: 0.8053

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L12013M	TCGA-37-A5EL	LUSC	TCGA	LFTPLTT	DEG_SCF_FBW7_1	0.1667
p.L12013M	DO223718	LUSC	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.1667
p.G12009V	TCGA-BF-A1PZ	SKCM	TCGA	LFTPLTT	DEG_SCF_FBW7_1	0.2778
p.G12009V	DO50279	SKCM	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.2778
p.E12016K	TCGA-BT-A0S7	BLCA	TCGA	LFTPLTT	DEG_SCF_FBW7_1	0.0833
p.E12016K	DO504	BLCA	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.0833
p.P12004H	TCGA-EO-A3B0	UCEC	TCGA	LFTPLTT	DEG_SCF_FBW7_1	0.7694
p.P12004H	DO229029	LICA	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.7694
p.P12004H	DO219773	UCEC	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.7694
p.A12014V	TCGA-FW-A3R5	SKCM	TCGA	LFTPLTT	DEG_SCF_FBW7_1	0.1389
p.A12014V	DO37406	SKCM	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.1389
p.F12002L	DO228202	LICA	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.587
p.T12006N	DO229018	LICA	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.5944
p.S12011Y	DO229036	LICA	ICGC	LFTPLTT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	12001:12007	LFTPLTT	FBXW7	0.9253	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons