DegronMD

Uniprot ID: Q9NRP7

Source protein: Serine/threonine-protein kinase 36

Source gene: STK36

Class: DEG_SCF_FBW7_1

Location: 344:351

E3 ligase: FBXW7

DEGRON score: 0.9571

ASA_SCORE: 86.175

COIL: 0.7863

CONS_SCORE: 0.3769

DSS_SCORE: 0.534

HELIX: 0.1886

FCONS_SCORE: 1.1261

RIG_SCORE: 0.7153

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G356E	TCGA-61-2109	OV	TCGA	LGATPQES	DEG_SCF_FBW7_1	0.1944
p.G356E	DO28982	OV	ICGC	LGATPQES	DEG_SCF_FBW7_1	0.1944
p.A346T	TCGA-AA-3966	COAD	TCGA	LGATPQES	DEG_SCF_FBW7_1	0.6028
p.A346T	DO10068	COAD	ICGC	LGATPQES	DEG_SCF_FBW7_1	0.6028
p.G345R	TCGA-B5-A3FC	UCEC	TCGA	LGATPQES	DEG_SCF_FBW7_1	0.6457
p.G345R	DO41871	UCEC	ICGC	LGATPQES	DEG_SCF_FBW7_1	0.6457
p.A339D	TCGA-FJ-A3Z7	BLCA	TCGA	LGATPQES	DEG_SCF_FBW7_1	0.1944
p.A339D	DO463	BLCA	ICGC	LGATPQES	DEG_SCF_FBW7_1	0.1944
p.V334M	DO222542	MELA	ICGC	LGATPQES	DEG_SCF_FBW7_1	0.0556
p.G356R	SIDM01664	Prostate Carcinoma	GDSC	LGATPQES	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRP7	Serine/threonine-protein kinase 36	DEG_SCF_FBW7_1	344:351	LGATPQES	FBXW7	0.9571	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons