DegronMD - Q9NRP7(STK36)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W366C	TCGA-44-7670	LUAD	TCGA	SGTGEVPSA	DEG_COP1_1	369:377	Mutation rewiring degron network	0.25
p.W366C	DO23555	LUAD	ICGC	SGTGEVPSA	DEG_COP1_1	369:377	Mutation rewiring degron network	0.25
p.G356E	TCGA-61-2109	OV	TCGA	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944
p.G356E	DO28982	OV	ICGC	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944
p.R276H	TCGA-85-A4CL	LUSC	TCGA	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation rewiring degron network	0.3056
p.R276H	TCGA-D1-A103	UCEC	TCGA	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation rewiring degron network	0.3056
p.R276H	DO45454	LUSC	ICGC	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation rewiring degron network	0.3056
p.R276H	DO42312	UCEC	ICGC	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation rewiring degron network	0.3056
p.S376F	TCGA-86-8672	LUAD	TCGA	SGTGEVPSA	DEG_COP1_1	369:377	Mutation altering degron motif	0.7982
p.S376F	DO25434	LUAD	ICGC	SGTGEVPSA	DEG_COP1_1	369:377	Mutation altering degron motif	0.7982
p.G270V	TCGA-A5-A1OF	UCEC	TCGA	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation altering degron motif	0.6421
p.G270V	DO42568	UCEC	ICGC	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation altering degron motif	0.6421
p.A346T	TCGA-AA-3966	COAD	TCGA	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6028
p.A346T	DO10068	COAD	ICGC	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6028
p.G345R	TCGA-B5-A3FC	UCEC	TCGA	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6457
p.G345R	DO41871	UCEC	ICGC	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation altering degron motif	0.6457
p.A339D	TCGA-FJ-A3Z7	BLCA	TCGA	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944
p.A339D	DO463	BLCA	ICGC	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944
p.S369L	TCGA-K4-AAQO	BLCA	TCGA	SGTGEVPSA	DEG_COP1_1	369:377	Mutation altering degron motif	0.7667
p.S369L	DO219030	BLCA	ICGC	SGTGEVPSA	DEG_COP1_1	369:377	Mutation altering degron motif	0.7667
p.R382W	DO230329	COCA	ICGC	SGTGEVPSA	DEG_COP1_1	369:377	Mutation rewiring degron network	0.1944
p.P272T	DO230336	COCA	ICGC	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation altering degron motif	0.7031
p.V334M	DO222542	MELA	ICGC	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.0556
p.D268A	DO36556	READ	ICGC	LGTPFTS	DEG_SCF_FBW7_1	269:275	Mutation rewiring degron network	0.3056
p.T384I	SIDM00140	Melanoma	GDSC	SGTGEVPSA	DEG_COP1_1	369:377	Mutation rewiring degron network	0.1389
p.T384I	ACH-000968	Skin Cancer	CCLE	SGTGEVPSA	DEG_COP1_1	369:377	Mutation rewiring degron network	0.1389
p.T384I	COLO-792	skin	COSMIC	SGTGEVPSA	DEG_COP1_1	369:377	Mutation rewiring degron network	0.1389
p.G356R	SIDM01664	Prostate Carcinoma	GDSC	LGATPQES	DEG_SCF_FBW7_1	344:351	Mutation rewiring degron network	0.1944
p.S376C	ACH-001392	Breast Cancer	CCLE	SGTGEVPSA	DEG_COP1_1	369:377	Mutation altering degron motif	0.7541

Kaplan plot for STK36 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STK36

UniProt ID: Q9NRP7

Entrez ID: 27148

Protein name: Serine/threonine-protein kinase 36 (EC 2.7.11.1) (Fused homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STK36 in