DegronMD

Uniprot ID: Q9NRP7

Source protein: Serine/threonine-protein kinase 36

Source gene: STK36

Class: DEG_COP1_1

Location: 369:377

E3 ligase: COP1

DEGRON score: 0.9977

ASA_SCORE: 75.3667

COIL: 0.9153

CONS_SCORE: 0.3491

DSS_SCORE: 0.6174

HELIX: 0.0367

FCONS_SCORE: 1.055

RIG_SCORE: 0.583

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W366C	TCGA-44-7670	LUAD	TCGA	SGTGEVPSA	DEG_COP1_1	0.25
p.W366C	DO23555	LUAD	ICGC	SGTGEVPSA	DEG_COP1_1	0.25
p.S376F	TCGA-86-8672	LUAD	TCGA	SGTGEVPSA	DEG_COP1_1	0.7982
p.S376F	DO25434	LUAD	ICGC	SGTGEVPSA	DEG_COP1_1	0.7982
p.S369L	TCGA-K4-AAQO	BLCA	TCGA	SGTGEVPSA	DEG_COP1_1	0.7667
p.S369L	DO219030	BLCA	ICGC	SGTGEVPSA	DEG_COP1_1	0.7667
p.R382W	DO230329	COCA	ICGC	SGTGEVPSA	DEG_COP1_1	0.1944
p.T384I	SIDM00140	Melanoma	GDSC	SGTGEVPSA	DEG_COP1_1	0.1389
p.T384I	ACH-000968	Skin Cancer	CCLE	SGTGEVPSA	DEG_COP1_1	0.1389
p.T384I	COLO-792	skin	COSMIC	SGTGEVPSA	DEG_COP1_1	0.1389
p.S376C	ACH-001392	Breast Cancer	CCLE	SGTGEVPSA	DEG_COP1_1	0.7541

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRP7	Serine/threonine-protein kinase 36	DEG_COP1_1	369:377	SGTGEVPSA	COP1	0.9977	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons