DegronMD

Uniprot ID: Q9NRP7

Source protein: Serine/threonine-protein kinase 36

Source gene: STK36

Class: DEG_SCF_FBW7_1

Location: 269:275

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 63.4714

COIL: 0.9046

CONS_SCORE: 0.3853

DSS_SCORE: 0.5571

HELIX: 0.0317

FCONS_SCORE: 1.1441

RIG_SCORE: 0.7125

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R276H	TCGA-85-A4CL	LUSC	TCGA	LGTPFTS	DEG_SCF_FBW7_1	0.3056
p.R276H	TCGA-D1-A103	UCEC	TCGA	LGTPFTS	DEG_SCF_FBW7_1	0.3056
p.R276H	DO45454	LUSC	ICGC	LGTPFTS	DEG_SCF_FBW7_1	0.3056
p.R276H	DO42312	UCEC	ICGC	LGTPFTS	DEG_SCF_FBW7_1	0.3056
p.G270V	TCGA-A5-A1OF	UCEC	TCGA	LGTPFTS	DEG_SCF_FBW7_1	0.6421
p.G270V	DO42568	UCEC	ICGC	LGTPFTS	DEG_SCF_FBW7_1	0.6421
p.P272T	DO230336	COCA	ICGC	LGTPFTS	DEG_SCF_FBW7_1	0.7031
p.D268A	DO36556	READ	ICGC	LGTPFTS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NRP7	Serine/threonine-protein kinase 36	DEG_SCF_FBW7_1	269:275	LGTPFTS	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons