DegronMD

Uniprot ID: O15440

Source protein: ATP-binding cassette sub-family C member 5

Source gene: ABCC5

Class: DEG_SCF_FBW7_2

Location: 786:793

E3 ligase: FBXW7

DEGRON score: 0.9054

ASA_SCORE: 100.8125

COIL: 0.8593

CONS_SCORE: 0.2766

DSS_SCORE: 0.438

HELIX: 0.1056

FCONS_SCORE: 0.953

RIG_SCORE: 0.7442

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P790L	TCGA-41-5651	GBM	TCGA	LGETPPVE	DEG_SCF_FBW7_2	0.7582
p.P790L	DO11501	GBM	ICGC	LGETPPVE	DEG_SCF_FBW7_2	0.7582
p.P790L	DO229459	SKCA	ICGC	LGETPPVE	DEG_SCF_FBW7_2	0.7582
p.A778V	TCGA-D3-A3C6	SKCM	TCGA	LGETPPVE	DEG_SCF_FBW7_2	0.1111
p.A778V	DO37507	SKCM	ICGC	LGETPPVE	DEG_SCF_FBW7_2	0.1111
p.L784M	TCGA-EY-A215	UCEC	TCGA	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.L784M	DO42665	UCEC	ICGC	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.L784M	SIDM01608	Endometrial Carcinoma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.L784M	ACH-000990	Endometrial/Uterine Cancer	CCLE	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.L784R	TCGA-FI-A2D5	UCEC	TCGA	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.L784R	DO41331	UCEC	ICGC	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.T800N	DO229027	LICA	ICGC	LGETPPVE	DEG_SCF_FBW7_2	0.5833
p.N783Y	SIDM01265	Plasma Cell Myeloma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	0.25
p.S803L	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	0.0556
p.S803L	ACH-001415	Bladder Cancer	CCLE	LGETPPVE	DEG_SCF_FBW7_2	0.0556
p.L784P	SIDM01619	Endometrial Carcinoma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	0.2778
p.L784P	ACH-000984	Endometrial/Uterine Cancer	CCLE	LGETPPVE	DEG_SCF_FBW7_2	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15440	ATP-binding cassette sub-family C member 5	DEG_SCF_FBW7_2	786:793	LGETPPVE	FBXW7	0.9054	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons