DegronMD - O15440(ABCC5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P790L	TCGA-41-5651	GBM	TCGA	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7582
p.P790L	DO11501	GBM	ICGC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7582
p.P790L	DO229459	SKCA	ICGC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation altering degron motif	0.7582
p.S1214P	TCGA-BG-A222	UCEC	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.2222
p.S1214P	DO42977	UCEC	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.2222
p.T1216M	TCGA-BR-6452	STAD	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation blocking phosphorylation signal	0.6111
p.T1216M	DO38404	STAD	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation blocking phosphorylation signal	0.6111
p.A778V	TCGA-D3-A3C6	SKCM	TCGA	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.1111
p.A778V	DO37507	SKCM	ICGC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.1111
p.V1209I	TCGA-DU-6392	LGG	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.5965
p.V1209I	DO233867	GACA	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.5965
p.V1209I	DO22237	LGG	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.5965
p.P1207H	TCGA-EE-A2MM	SKCM	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.6583
p.P1207H	DO37770	SKCM	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.6583
p.L784M	TCGA-EY-A215	UCEC	TCGA	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.L784M	DO42665	UCEC	ICGC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.L784M	SIDM01608	Endometrial Carcinoma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.L784M	ACH-000990	Endometrial/Uterine Cancer	CCLE	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.L784R	TCGA-FI-A2D5	UCEC	TCGA	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.L784R	DO41331	UCEC	ICGC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.R1201M	TCGA-VS-A94Z	CESC	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.3056
p.R1201M	DO51634	CESC	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.3056
p.S1214Y	DO228952	LICA	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.2222
p.L1210I	DO229018	LICA	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.6063
p.T800N	DO229027	LICA	ICGC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation blocking phosphorylation signal	0.5833
p.N783Y	SIDM01265	Plasma Cell Myeloma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.25
p.S803L	SIDM01130	Squamous Cell Lung Carcinoma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.S803L	ACH-001415	Bladder Cancer	CCLE	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.0556
p.E1196Q	SIDM01093	Cervical Carcinoma	GDSC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.1667
p.E1196Q	ACH-000556	Cervical Cancer	CCLE	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.1667
p.E1196Q	SiHa	cervix	COSMIC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation rewiring degron network	0.1667
p.L784P	SIDM01619	Endometrial Carcinoma	GDSC	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.L784P	ACH-000984	Endometrial/Uterine Cancer	CCLE	LGETPPVE	DEG_SCF_FBW7_2	786:793	Mutation rewiring degron network	0.2778
p.S1204T	HCC1569	breast	COSMIC	YRENLPLVL	DEG_APCC_DBOX_1	1202:1210	Mutation altering degron motif	0.7116

Kaplan plot for ABCC5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCC5

UniProt ID: O15440

Entrez ID: 10057

Protein name: ATP-binding cassette sub-family C member 5 (EC 7.6.2.-) (EC 7.6.2.2) (Multi-specific organic anion transporter C) (MOAT-C) (Multidrug resistance-associated protein 5) (SMRP) (pABC11)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABCC5 in