DegronMD

Uniprot ID: O15440

Source protein: ATP-binding cassette sub-family C member 5

Source gene: ABCC5

Class: DEG_APCC_DBOX_1

Location: 1202:1210

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6997

ASA_SCORE: 71.2889

COIL: 0.6076

CONS_SCORE: 0.6738

DSS_SCORE: 0.2104

HELIX: 0.1593

FCONS_SCORE: 1.1571

RIG_SCORE: 0.8655

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1214P	TCGA-BG-A222	UCEC	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	0.2222
p.S1214P	DO42977	UCEC	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.2222
p.T1216M	TCGA-BR-6452	STAD	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	0.6111
p.T1216M	DO38404	STAD	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.6111
p.V1209I	TCGA-DU-6392	LGG	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	0.5965
p.V1209I	DO233867	GACA	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.5965
p.V1209I	DO22237	LGG	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.5965
p.P1207H	TCGA-EE-A2MM	SKCM	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	0.6583
p.P1207H	DO37770	SKCM	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.6583
p.R1201M	TCGA-VS-A94Z	CESC	TCGA	YRENLPLVL	DEG_APCC_DBOX_1	0.3056
p.R1201M	DO51634	CESC	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.3056
p.S1214Y	DO228952	LICA	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.2222
p.L1210I	DO229018	LICA	ICGC	YRENLPLVL	DEG_APCC_DBOX_1	0.6063
p.E1196Q	SIDM01093	Cervical Carcinoma	GDSC	YRENLPLVL	DEG_APCC_DBOX_1	0.1667
p.E1196Q	ACH-000556	Cervical Cancer	CCLE	YRENLPLVL	DEG_APCC_DBOX_1	0.1667
p.E1196Q	SiHa	cervix	COSMIC	YRENLPLVL	DEG_APCC_DBOX_1	0.1667
p.S1204T	HCC1569	breast	COSMIC	YRENLPLVL	DEG_APCC_DBOX_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15440	ATP-binding cassette sub-family C member 5	DEG_APCC_DBOX_1	1202:1210	YRENLPLVL	APC,CDC20,FZR1	0.6997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons