DegronMD

Uniprot ID: P46531

Source protein: Neurogenic locus notch homolog protein 1

Source gene: NOTCH1

Class: DEG_SCF_FBW7_1

Location: 2129:2136

E3 ligase: FBXW7

DEGRON score: 0.9991

ASA_SCORE: 76.2625

COIL: 0.9568

CONS_SCORE: 0.2514

DSS_SCORE: 0.5125

HELIX: 0.0125

FCONS_SCORE: 0.6965

RIG_SCORE: 0.6277

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2138Q	TCGA-BF-A1Q0	SKCM	TCGA	LGGTPTLS	DEG_SCF_FBW7_1	0.2778
p.P2138Q	DO47374	SKCM	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.2778
p.G2130W	TCGA-EE-A2ML	SKCM	TCGA	LGGTPTLS	DEG_SCF_FBW7_1	0.6714
p.G2130W	DO37408	SKCM	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.6714
p.V2119M	TCGA-XF-AAN7	BLCA	TCGA	LGGTPTLS	DEG_SCF_FBW7_1	0.0556
p.V2119M	DO51946	BLCA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.0556
p.S2121R	DO228952	LICA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.5556
p.H2125Q	DO229015	LICA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.2222
p.H2125Q	SIDM01237	Hepatocellular Carcinoma	GDSC	LGGTPTLS	DEG_SCF_FBW7_1	0.2222
p.H2125Q	ACH-001021	Liver Cancer	CCLE	LGGTPTLS	DEG_SCF_FBW7_1	0.2222
p.H2125Q	ACH-001028	Rhabdoid	CCLE	LGGTPTLS	DEG_SCF_FBW7_1	0.2222
p.H2125Q	C3A	liver	COSMIC	LGGTPTLS	DEG_SCF_FBW7_1	0.2222
p.G2126R	DO228584	MALY	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.25
p.G2126R	DO232224	PBCA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.25
p.G2126R	DO36386	READ	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	0.25
p.P2133S	SIDM01126	Small Cell Lung Carcinoma	GDSC	LGGTPTLS	DEG_SCF_FBW7_1	0.6752
p.P2133S	SIDM00673	Breast Carcinoma	GDSC	LGGTPTLS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46531	Neurogenic locus notch homolog protein 1	DEG_SCF_FBW7_1	2129:2136	LGGTPTLS	FBXW7	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons