DegronMD - P46531(NOTCH1)

GO - Biological processes (BP): animal organ regeneration [GO:0031100]; aortic valve morphogenesis [GO:0003180]; apoptotic process involved in embryonic digit morphogenesis [GO:1902263]; arterial endothelial cell differentiation [GO:0060842]; astrocyte differentiation [GO:0048708]; atrioventricular node development [GO:0003162]; atrioventricular valve morphogenesis [GO:0003181]; auditory receptor cell fate commitment [GO:0009912]; axon guidance [GO:0007411]; branching morphogenesis of an epithelial tube [GO:0048754]; cardiac atrium morphogenesis [GO:0003209]; cardiac chamber formation [GO:0003207]; cardiac epithelial to mesenchymal transition [GO:0060317]; cardiac left ventricle morphogenesis [GO:0003214]; cardiac muscle cell proliferation [GO:0060038]; cardiac muscle tissue morphogenesis [GO:0055008]; cardiac right atrium morphogenesis [GO:0003213]; cardiac right ventricle formation [GO:0003219]; cardiac septum morphogenesis [GO:0060411]; cardiac vascular smooth muscle cell development [GO:0060948]; cardiac ventricle morphogenesis [GO:0003208]; cell differentiation in spinal cord [GO:0021515]; cell fate specification [GO:0001708]; cell migration involved in endocardial cushion formation [GO:0003273]; cellular response to follicle-stimulating hormone stimulus [GO:0071372]; cellular response to tumor cell [GO:0071228]; cellular response to vascular endothelial growth factor stimulus [GO:0035924]; cilium assembly [GO:0060271]; collecting duct development [GO:0072044]; compartment pattern specification [GO:0007386]; coronary artery morphogenesis [GO:0060982]; coronary sinus valve morphogenesis [GO:0003182]; coronary vein morphogenesis [GO:0003169]; determination of left/right symmetry [GO:0007368]; distal tubule development [GO:0072017]; embryonic hindlimb morphogenesis [GO:0035116]; endocardial cell differentiation [GO:0060956]; endocardial cushion morphogenesis [GO:0003203]; endocardium development [GO:0003157]; endocardium morphogenesis [GO:0003160]; endoderm development [GO:0007492]; epithelial to mesenchymal transition [GO:0001837]; epithelial to mesenchymal transition involved in endocardial cushion formation [GO:0003198]; forebrain development [GO:0030900]; foregut morphogenesis [GO:0007440]; gene expression [GO:0010467]; glomerular mesangial cell development [GO:0072144]; growth involved in heart morphogenesis [GO:0003241]; hair follicle morphogenesis [GO:0031069]; heart development [GO:0007507]; heart looping [GO:0001947]; heart trabecula morphogenesis [GO:0061384]; homeostasis of number of cells within a tissue [GO:0048873]; humoral immune response [GO:0006959]; immune response [GO:0006955]; inflammatory response to antigenic stimulus [GO:0002437]; interleukin-17-mediated signaling pathway [GO:0097400]; in utero embryonic development [GO:0001701]; keratinocyte differentiation [GO:0030216]; left/right axis specification [GO:0070986]; liver development [GO:0001889]; lung development [GO:0030324]; mesenchymal cell development [GO:0014031]; mitral valve formation [GO:0003192]; negative regulation of anoikis [GO:2000811]; negative regulation of biomineral tissue development [GO:0070168]; negative regulation of BMP signaling pathway [GO:0030514]; negative regulation of calcium ion-dependent exocytosis [GO:0045955]; negative regulation of canonical Wnt signaling pathway [GO:0090090]; negative regulation of cardiac muscle hypertrophy [GO:0010614]; negative regulation of catalytic activity [GO:0043086]; negative regulation of cell adhesion molecule production [GO:0060354]; negative regulation of cell-cell adhesion mediated by cadherin [GO:2000048]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of cell proliferation involved in heart valve morphogenesis [GO:0003252]; negative regulation of cell-substrate adhesion [GO:0010812]; negative regulation of cold-induced thermogenesis [GO:0120163]; negative regulation of endothelial cell chemotaxis [GO:2001027]; negative regulation of extracellular matrix constituent secretion [GO:0003332]; negative regulation of gene expression [GO:0010629]; negative regulation of glial cell proliferation [GO:0060253]; negative regulation of inner ear auditory receptor cell differentiation [GO:0045608]; negative regulation of myoblast differentiation [GO:0045662]; negative regulation of myotube differentiation [GO:0010832]; negative regulation of neurogenesis [GO:0050768]; negative regulation of oligodendrocyte differentiation [GO:0048715]; negative regulation of ossification [GO:0030279]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of photoreceptor cell differentiation [GO:0046533]; negative regulation of pro-B cell differentiation [GO:2000974]; negative regulation of stem cell differentiation [GO:2000737]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; neural tube development [GO:0021915]; neuronal stem cell population maintenance [GO:0097150]; Notch signaling involved in heart development [GO:0061314]; Notch signaling pathway [GO:0007219]; Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation [GO:0003270]; oligodendrocyte differentiation [GO:0048709]; outflow tract morphogenesis [GO:0003151]; pericardium morphogenesis [GO:0003344]; positive regulation of aorta morphogenesis [GO:1903849]; positive regulation of apoptotic process involved in morphogenesis [GO:1902339]; positive regulation of astrocyte differentiation [GO:0048711]; positive regulation of BMP signaling pathway [GO:0030513]; positive regulation of cardiac epithelial to mesenchymal transition [GO:0062043]; positive regulation of cardiac muscle cell proliferation [GO:0060045]; positive regulation of cell migration [GO:0030335]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of endothelial cell differentiation [GO:0045603]; positive regulation of epithelial cell proliferation [GO:0050679]; positive regulation of ERK1 and ERK2 cascade [GO:0070374]; positive regulation of gene expression [GO:0010628]; positive regulation of keratinocyte differentiation [GO:0045618]; positive regulation of neuroblast proliferation [GO:0002052]; positive regulation of Notch signaling pathway [GO:0045747]; positive regulation of Ras protein signal transduction [GO:0046579]; positive regulation of receptor signaling pathway via JAK-STAT [GO:0046427]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia [GO:0061419]; positive regulation of transcription of Notch receptor target [GO:0007221]; positive regulation of viral genome replication [GO:0045070]; prostate gland epithelium morphogenesis [GO:0060740]; protein catabolic process [GO:0030163]; protein import into nucleus [GO:0006606]; pulmonary valve morphogenesis [GO:0003184]; regulation of epithelial cell proliferation involved in prostate gland development [GO:0060768]; regulation of extracellular matrix assembly [GO:1901201]; regulation of somitogenesis [GO:0014807]; regulation of transcription, DNA-templated [GO:0006355]; regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [GO:0003256]; response to corticosteroid [GO:0031960]; response to lipopolysaccharide [GO:0032496]; response to muramyl dipeptide [GO:0032495]; secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development [GO:0060528]; skeletal muscle cell differentiation [GO:0035914]; somatic stem cell division [GO:0048103]; spermatogenesis [GO:0007283]; sprouting angiogenesis [GO:0002040]; T-helper 17 type immune response [GO:0072538]; tissue regeneration [GO:0042246]; tube formation [GO:0035148]; vasculogenesis involved in coronary vascular morphogenesis [GO:0060979]; venous endothelial cell differentiation [GO:0060843]; ventricular septum morphogenesis [GO:0060412]; ventricular trabecula myocardium morphogenesis [GO:0003222] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S2523L	TCGA-AR-A2LR	BRCA	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.5556
p.S2523L	DO4935	BRCA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.5556
p.S2523L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.5556
p.S2523L	ACH-000960	Leukemia	CCLE	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.5556
p.S2523L	REH	haematopoietic and lymphoid tissue	COSMIC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.5556
p.P2138Q	TCGA-BF-A1Q0	SKCM	TCGA	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2778
p.P2138Q	DO47374	SKCM	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2778
p.P2514T	TCGA-CG-5726	STAD	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.5919
p.P2514T	TCGA-FS-A1ZP	SKCM	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.5919
p.P2514T	DO37703	SKCM	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.5919
p.P2514T	DO38483	STAD	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.5919
p.P2512T	TCGA-EE-A2M6	SKCM	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.7031
p.P2512T	DO37976	SKCM	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.7031
p.G2130W	TCGA-EE-A2ML	SKCM	TCGA	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation altering degron motif	0.6714
p.G2130W	DO37408	SKCM	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation altering degron motif	0.6714
p.P2525Q	TCGA-FS-A1ZC	SKCM	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation rewiring degron network	0.0556
p.P2525Q	DO37487	SKCM	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation rewiring degron network	0.0556
p.S2521F	TCGA-G2-A2EO	BLCA	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.6111
p.S2521F	DO456	BLCA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.6111
p.P2498T	TCGA-G7-6797	KIRP	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation rewiring degron network	0.0556
p.P2498T	DO20917	KIRP	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation rewiring degron network	0.0556
p.V2119M	TCGA-XF-AAN7	BLCA	TCGA	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.0556
p.V2119M	DO51946	BLCA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.0556
p.P2512L	DO233693	GACA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation altering degron motif	0.7582
p.S2121R	DO228952	LICA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation blocking phosphorylation signal	0.5556
p.H2125Q	DO229015	LICA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2222
p.H2125Q	SIDM01237	Hepatocellular Carcinoma	GDSC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2222
p.H2125Q	ACH-001021	Liver Cancer	CCLE	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2222
p.H2125Q	ACH-001028	Rhabdoid	CCLE	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2222
p.H2125Q	C3A	liver	COSMIC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.2222
p.G2126R	DO228584	MALY	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.25
p.G2126R	DO232224	PBCA	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.25
p.G2126R	DO36386	READ	ICGC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation rewiring degron network	0.25
p.S2516F	DO220897	MELA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.75
p.S2516F	DO31769	OV	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	2508:2515	Mutation blocking phosphorylation signal	0.75
p.P2133S	SIDM01126	Small Cell Lung Carcinoma	GDSC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation altering degron motif	0.6752
p.P2133S	SIDM00673	Breast Carcinoma	GDSC	LGGTPTLS	DEG_SCF_FBW7_1	2129:2136	Mutation altering degron motif	0.6752

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NOTCH1

UniProt ID: P46531

Entrez ID: 4851

Protein name: Neurogenic locus notch homolog protein 1 (Notch 1) (hN1) (Translocation-associated notch protein TAN-1) [Cleaved into: Notch 1 extracellular truncation (NEXT); Notch 1 intracellular domain (NICD)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NOTCH1 in