DegronMD

Uniprot ID: P46531

Source protein: Neurogenic locus notch homolog protein 1

Source gene: NOTCH1

Class: DEG_SCF_FBW7_2

Location: 2508:2515

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 50.9125

COIL: 0.916

CONS_SCORE: 0.545

DSS_SCORE: 0.7163

HELIX: 0.0201

FCONS_SCORE: 1.0487

RIG_SCORE: 0.6023

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2512L	DO233693	GACA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.7582
p.S2516F	DO220897	MELA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.75
p.S2516F	DO31769	OV	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.75
p.P2512T	TCGA-EE-A2M6	SKCM	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.7031
p.P2512T	DO37976	SKCM	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.7031
p.S2521F	TCGA-G2-A2EO	BLCA	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.6111
p.S2521F	DO456	BLCA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.6111
p.P2514T	TCGA-CG-5726	STAD	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.5919
p.P2514T	TCGA-FS-A1ZP	SKCM	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.5919
p.P2514T	DO37703	SKCM	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.5919
p.P2514T	DO38483	STAD	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.5919
p.S2523L	TCGA-AR-A2LR	BRCA	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.5556
p.S2523L	DO4935	BRCA	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.5556
p.S2523L	SIDM00447	B-Lymphoblastic Leukemia	GDSC	PFLTPSPE	DEG_SCF_FBW7_2	0.5556
p.S2523L	ACH-000960	Leukemia	CCLE	PFLTPSPE	DEG_SCF_FBW7_2	0.5556
p.S2523L	REH	haematopoietic_and_lymphoid_tissue	COSMIC	PFLTPSPE	DEG_SCF_FBW7_2	0.5556
p.P2525Q	TCGA-FS-A1ZC	SKCM	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.0556
p.P2525Q	DO37487	SKCM	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.0556
p.P2498T	TCGA-G7-6797	KIRP	TCGA	PFLTPSPE	DEG_SCF_FBW7_2	0.0556
p.P2498T	DO20917	KIRP	ICGC	PFLTPSPE	DEG_SCF_FBW7_2	0.0556

Showing 1 to 20 of 20 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P46531	Neurogenic locus notch homolog protein 1	DEG_SCF_FBW7_2	2508:2515	PFLTPSPE	FBXW7	0.9986	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons