DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 696:703

E3 ligase: FBXW7

DEGRON score: 0.8569

ASA_SCORE: 90.1875

COIL: 0.876

CONS_SCORE: 0

DSS_SCORE: 0.5817

HELIX: 0.0151

FCONS_SCORE: 0

RIG_SCORE: 0.6582

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F690I	TCGA-86-8669	LUAD	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.1667
p.F690I	DO25574	LUAD	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.1667
p.P712T	TCGA-95-7039	LUAD	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.0833
p.P712T	DO23907	LUAD	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.0833
p.R704I	TCGA-AX-A2HC	UCEC	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.R704I	TCGA-D5-6537	COAD	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.R704I	DO9530	COAD	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.R704I	DO41572	UCEC	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.S688P	TCGA-BR-4279	STAD	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.1111
p.S688P	DO38811	STAD	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.1111
p.S688L	TCGA-CF-A27C	BLCA	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.1111
p.S688L	DO828	BLCA	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.1111
p.P706S	TCGA-D3-A1Q5	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.P706S	DO37827	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.G693E	TCGA-D3-A2JF	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.G693E	TCGA-D3-A8GC	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.G693E	TCGA-D3-A8GQ	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.G693E	DO50281	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.G693E	DO51246	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.G693E	DO38153	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.T694I	TCGA-DU-6392	LGG	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.2778
p.T694I	DO22237	LGG	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.2778
p.E692K	TCGA-EE-A2MR	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.2222
p.E692K	DO37819	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.2222
p.P706L	TCGA-FR-A8YC	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.P706L	DO50301	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.P712L	TCGA-GF-A6C8	SKCM	TCGA	LGLTPLNT	DEG_SCF_FBW7_1	0.0833
p.P712L	DO48765	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.0833
p.E711D	DO234363	ESAD	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.1111
p.H705N	DO228978	LICA	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.2778
p.P700Q	DO229026	LICA	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.7035
p.D713N	DO220879	MELA	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.0556
p.G697R	DO222843	MELA	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.6457
p.G693R	DO37946	SKCM	ICGC	LGLTPLNT	DEG_SCF_FBW7_1	0.25
p.R704G	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.R704G	ACH-000917	Esophageal Cancer	CCLE	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.R704G	TE-4	oesophagus	COSMIC	LGLTPLNT	DEG_SCF_FBW7_1	0.3056
p.P710H	SIDM01127	Non-Small Cell Lung Carcinoma	GDSC	LGLTPLNT	DEG_SCF_FBW7_1	0.1389
p.P710H	ACH-000628	Lung Cancer	CCLE	LGLTPLNT	DEG_SCF_FBW7_1	0.1389
p.P710H	NCI-H596	lung	COSMIC	LGLTPLNT	DEG_SCF_FBW7_1	0.1389
p.P700L	SIDM01066	Melanoma	GDSC	LGLTPLNT	DEG_SCF_FBW7_1	0.7582
p.P700L	ACH-000650	Skin Cancer	CCLE	LGLTPLNT	DEG_SCF_FBW7_1	0.7582
p.P700L	IGR-37	skin	COSMIC	LGLTPLNT	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGLTPLNT

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of LGLTPLNT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	696:703	LGLTPLNT	FBXW7	0.8569	More...