DegronMD

Uniprot ID: Q96MT3

Source protein: Prickle-like protein 1

Source gene: PRICKLE1

Class: LIG_APCC_ABBA_1

Location: 752:757

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9094

ASA_SCORE: 77.4333

COIL: 0.7683

CONS_SCORE: 0.2708

DSS_SCORE: 0.3798

HELIX: 0.1478

FCONS_SCORE: 0.6731

RIG_SCORE: 0.7648

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R750Q	TCGA-R6-A8W8	ESCA	TCGA	LGLYGE	LIG_APCC_ABBA_1	0.2778
p.R750W	TCGA-WE-A8ZT	SKCM	TCGA	LGLYGE	LIG_APCC_ABBA_1	0.2778
p.R750W	DO51290	SKCM	ICGC	LGLYGE	LIG_APCC_ABBA_1	0.2778
p.G753E	TCGA-Z2-AA3V	SKCM	TCGA	LGLYGE	LIG_APCC_ABBA_1	0.6087
p.G753E	DO51303	SKCM	ICGC	LGLYGE	LIG_APCC_ABBA_1	0.6087
p.P746S	DO229005	COCA	ICGC	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.P746S	DO229354	LAML	ICGC	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.P746S	DO52365	LUSC	ICGC	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.N745K	DO44792	LICA	ICGC	LGLYGE	LIG_APCC_ABBA_1	0.1389
p.P746Q	SIDM00401	Melanoma	GDSC	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.P746Q	ACH-000614	Skin Cancer	CCLE	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.P746Q	ACH-002461	Skin Cancer	CCLE	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.P746Q	RVH-421	skin	COSMIC	LGLYGE	LIG_APCC_ABBA_1	0.1667
p.D759N	SIDM00560	Gastric Carcinoma	GDSC	LGLYGE	LIG_APCC_ABBA_1	0.2778
p.D759N	ACH-000678	Gastric Cancer	CCLE	LGLYGE	LIG_APCC_ABBA_1	0.2778
p.D759N	MKN7	stomach	COSMIC	LGLYGE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96MT3	Prickle-like protein 1	LIG_APCC_ABBA_1	752:757	LGLYGE	APC,CDC20,FZR1	0.9094	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons